Phenoperidine 379used to control high blood pressure), thereby producing extremely low blood
pressure. Cases of major circulatory collapse are known.
Cancer.Not enough scientific information to report.
Pregnancy.Experimentation with mice has shown birth defects to be less
likely from phenoperidine than from other drugs with similar medical uses,
but that finding does not mean the substance is safe for use during pregnancy.
Clinical observations have detected no fetal or newborn injury when pheno-
peridine was used as an anesthetic in childbirth.
Additional scientific information may be found in:
Grummitt, R.M., and V.A. Goat. “Intracranial Pressure after Phenoperidine.”Anaesthe-
sia39 (1984): 565–67.
Macrae, D.J., et al. “Double-Blind Comparison of the Efficacy of Extradural Dia-
morphine, Extradural Phenoperidine and I.m. Diamorphine Following Caesar-
ean Section.”British Journal of Anaesthesia59 (1987): 354–59.
“Phenoperidine HCl.” InTherapeutic Drugs, ed. C. Dollery. 2d ed. New York: Churchill
Livingstone, 1999. P89–P90.
Werner, D., et al. “A Comparison of Diazepam and Phenoperidine in Premedication
for Upper Gastrointestinal Endoscopy: A Randomized Double Blind Controlled
Study.”European Journal of Clinical Pharmacology22 (1982): 143–45.
Whalley, D.G., et al. “A Comparison of the Incidence of Cardiac Arrhythmia during
Two Methods of Anaesthesia for Dental Extractions.”British Journal of Anaesthe-
sia48 (1976): 1207–10.