Internal Medicine

P1: RLJ/OZN P2: KUF

0521779407-D-01 CUNY1086/Karliner 0 521 77940 7 June 13, 2007 7:41

Dent’s Disease Dermatofibroma 469

specific therapy

■Thiazide diuretics to prevent stone formation may be of benefit.

follow-up

■To ensure growth and follow renal function and nephrocalcinosis

complications and prognosis

■Often results in progressive renal insufficiency secondary to nephro-

calcinosis and recurrent renal stones

Dermatofibroma.....................................

JEFFREY P. CALLEN, MD

history & physical

History

■Asymptomatic or symptoms related to surface trauma such as shav-

ing

■More common in women

■May represent the end stage of an insect bite or folliculitis

■Possibly more common in patients with lupus erythematosus

Signs & Symptoms

■Leg lesions are most common, but the arms and trunk might also be

affected.

■Flesh-colored, erythematous or hyperpigmented papule or nodule

with little surface change

■When the lesion is pinched, it will dimple centrally.

tests

■Skin biopsy is diagnostic

differential diagnosis

■Includes keloid, hypertrophic scar, melanoma, basal cell carcinoma,

Kaposi sarcoma, dermatofibrosarcoma protuberans

management

■Surgical removal for symptomatic lesions

specific therapy

■None