Internal Medicine

P1: OXT/OZN/JDO P2: PSB

0521779407-E-01 CUNY1086/Karliner 0 521 77940 7 June 4, 2007 21:10

Eyelid Lesions Fanconi Syndrome 563

■Sebacious gland carcinomas (SGC) account for 2–4% of eyelid malig-

nancies.

■A “recurrent stye or chalazoin” in the same eyelid location is possibly

a SGC.

tests

■All such lesions require a biopsy with a histologic evaluation.

differential diagnosis

■BCC is the most common eyelid malignancy (>90%).

■Much less commonly: sebaceous carcinoma, squamous cell carci-

noma, melanoma,

■Kaposi’s sarcoma, and rarer malignancies.

management

■Most eyelid tumors managed surgically with excellent cosmetics.

■In selected cases, radiation or cryotherapy.

■Metastatic patterns of eyelid malignancies similar to other head/

neck sites.

specific therapy

n/a

follow-up

n/a

complications and prognosis

n/a

Fanconi Syndrome...................................

MICHEL BAUM, MD

history & physical

■Presentation varies with underlying etiology.

■Polydipsia and polyuria

■Children present with failure to thrive, short stature and rickets.

■Adults develop osteomalacia.

tests

■Hyperchloremic metabolic acidosis, hypophosphatemia, hypo-

kalemia

■Glucosuria, generalized aminoaciduria, phosphaturia (fractional

excretion >20%)