192 DISEASES/DISORDERS
Epidermolysis Bullosa Acquisita
Erythematous plaques and vesicles leading to ulcerations (Figure 12.20a).
Common sites: face, concave pinnae, axillae, ventral abdomen, inguinum.
Lesions nearly always affect oral mucosa.
Footpad sloughing (Figure 12.20b,c).
Areas of pressure or trauma commonly affected (Figure 12.20d).
Scarring is common.
Variable pruritus and pain.
Anorexia, depression, and fever.
DIFFERENTIAL DIAGNOSIS
Pemphigus Complex
PF:
Bacterial folliculitis
Neutrophilic or eosinophilic furunculosis
Dermatophytosis
Demodicosis
Leishmaniasis
Sebaceous adenitis
Keratinization disorders
Discoid or cutaneous lupus erythematosus
Pemphigus erythematosus
Subcorneal pustular dermatosis
Drug eruption
Erythema multiforme
Zinc-responsive dermatitis
Dermatomyositis
Tyrosinemia
Epitheliotropic lymphoma
Lymphoreticular malignancies
Superficial necrolytic dermatosis
Uveodermatologic syndrome
Sterile eosinophilic pustulosis
Linear IgA dermatosis.
PE:
Pemphigus foliaceus (facially oriented)
Systemic lupus erythematosus
Discoid lupus erythematosus
Bacterial folliculitis
Neutrophilic or eosinophilic furunculosis
Demodicosis
Dermatophytosis