198 DISEASES/DISORDERS
Chlorambucil: leukopenia, thrombocytopenia, nephrotoxicity, and hepatotox-
icity
Chrysotherapy: leukopenia, thrombocytopenia, nephrotoxicity, dermatitis,
stomatitis, and allergic reactions
Cyclosporine: vomiting, diarrhea, hirsutism, psoriasiform lichenoid-like der-
matitis
Mycophenolate mofetil: vomiting, diarrhea, lymphopenia
Colchicine: vomiting, diarrhea, rare bone marrow suppression
Immunosuppression: can predispose animal to demodectic mange, cutaneous
and systemic bacterial and fungal infection.
Expected Course and Prognosis – Pemphigus Complex
PF, PV, PEP/Pveg:
Lifelong therapy with corticosteroids and cytotoxic drugs needed; remission rare
Routine monitoring paramount
Side effects of medications may affect quality of life
May be fatal if untreated (especially PV)
Secondary infections cause morbidity and possible mortality (especially PV).
PE:
Relatively benign and self-limiting
Oral corticosteroids may eventually be tapered to low maintenance doses or may
be stopped in some patients
Dermatitis worsens if untreated; systemic symptoms are rare
Prognosis fair.
PP:
Grave prognosis due to underlying neoplasia.
Expected Course and Prognosis – Pemphigoid Complex
Lifelong therapy necessary.
In severe cases, aggressive initial intervention is usually required; some cases do not
respond to treatment.
Chronic cases may be controlled with cycline antibiotics/niacinamide and/or topical
therapy.
Morbidity is associated with secondary bacterial infection.
Expected Course and Prognosis – Epidermolysis Bullosa Acquisita
Lifelong therapy may be necessary.
In severe cases, aggressive initial intervention is usually required; some cases do not
respond to treatment.
Morbidity is associated with oral lesions and secondary bacterial infection.