624 DISEASES/DISORDERS
Surgical excision of individual lesions
Application of DMSO may inhibit amyloid synthesis
Cutaneous mucinosis (secondary):
Antihistamines: diphenhydramine 1 mg/kg PO BID; hydroxyzine 1 mg/kg
PO BID
Corticosteroids: prednisolone 0.5 mg/kg PO q24h then tapered dosage
Nodular dermatofibrosis:
Surgical excision of internal neoplasia
Surgical excision of individual lesions
Paraneoplastic pemphigus:
Surgical excision of internal neoplasia
Treatment similar to pemphigus foliaceus
Prednisolone: 1.1–2.2 mg/kg PO divided BID to initiate control, tapering to
maintenance at 0.5 mg/kg PO q48–72h
More than half of patients require the addition of other immunomodulating
drugs
Azathioprine: 2.2 mg/kg PO q24h, then EOD
Superficial necrolytic dermatitis:Surgical excision of tumor
Patient survival: 6 months without tumor excision; euthanasia most often
due to diabetic crisis or hepatic failure
Treatment of secondary bacterial folliculitis and/orMalasseziadermatitis
with appropriate antimicrobials
Prednisolone 0.5 mg/kg q24h; taper dosage and discontinue as soon as pos-
sible: temporary relief of pruritus and inflammation; may exacerbate dia-
betes mellitus; may aggravate hepatopathy
Octreotide 2–3.2μg/kg by subcutaneous injection BID to QID: somatostatin
analog; nonresected glucagon-producing pancreatic tumor
Amino acid infusion: intravenous administration of amino acids to replen-
ish serum levels from excessive hepatic catabolism
10% crystalline amino acid solution; 25 mL/kg over 8 h
3% amino acid and electrolyte solutions; 25 mL/kg over 8 h
Initial replacement therapy twice weekly until symptoms improve
Maintenance infusions every 7–14 days as indicated by patient response. Feline preneoplastic dermatoses:
Actinic keratoses:
Avoid exposure to UVL by keeping patients indoors and by applying sun-
block
Topical corticosteroids: reduce localized areas of inflammation
Prednisolone (0.5 mg/kg PO tapered dosage): reduce significant inflamma-
tion
Cephalexin (22 mg/kg PO BID): secondary bacterial furunculosis; alterna-
tive antibiotics selected by culture and sensitivity test results
Tretinoin 0.1% (Retin-A): apply daily to individual lesions for 14 days; then
2–3 times weekly; may cause irritation
Surgical excision of affected tissue