APPENDIX B DRUG FORMULARY 787
Lomustine (CCNU)(CeeNU)Anticancer drug –alkylating agent in thenitrosourea class.Chemotherapeutic agent.Highly lipid soluble andcrosses blood–brainbarrier. Used forlymphoma and braintumors.Myelosuppression,hepatotoxicosis, vomiting.Administering on emptystomach decreasesnausea. Monitorhemogram for evidenceof myelosuppression.10, 40, 100 mgcapsules.Dog: 70–90 mg/m2
every4 weeks po. For braintumors 60–80 mg/m2q6–8 weeks po.Cat: 50–60 mg/m2poevery 3–6 weeks or 10 mgper cat po every 3 weeks.Lufenuron (Program)Antiparasitic. Used forcontrolling fleas inanimals. Inhibitsdevelopment in hatchingfleas. May be used fordermatophytes in dogsand cats, althoughefficacy has beenquestioned by someexperts.Adverse effects have notbeen reported. Appears tobe relatively safe duringpregnancy and in younganimals.Lufenuron may controlflea development withadministration once every30 days in animals.45, 90, 135, 204.9,409.8 mg tablets;135 and 270 mgsuspension per unitpack.Dog: 10 mg/kg po every30 days.Cat: 30 mg/kg po every30 days Cat injection:10 mg/kg SC every 6months.Antifungal dose – dog:80 mg/kg; cat: 100 mg/kg.In endemic areas (e.g.,catteries) treat cats once amonth.Lufenuron +milbemycin oxime(Sentinel tablets andFlavor Tabs)Combination of twoantiparasitic drugs. SeeLufenuron or Milbemycinoxime. Used to protectagainst fleas, heartworms,roundworms,hookworms, andwhipworms.See Lufenuron orMilbemycin oxime.See Lufenuron orMilbemycin oxime.Milbemycinoxime/lufenuronratio is as follows:2.3/46 mg tablets;5.75/115, 11.5/230,and 23/460 mgFlavor Tabs.Dog: administer onetablet, every 30 days.Each tablet formulated forsize of dog.Cat: This product is notregistered for cats.(continued)