Article
Tailored Immunogens Direct Affinity Maturation
toward HIV Neutralizing Antibodies
Graphical Abstract
Highlights
d Designed boosting immunogens to follow a VRC01-class
germline-targeting prime
d Boosted Abs selectively incorporate VRC01-class somatic
mutations
d Sequential boosts elicit VRC01-class mAbs with broad
neutralization of N276A viruses
d Vaccine-elicited VRC01-class mAbs neutralize one fully
native HIV isolate
Authors
Bryan Briney, Devin Sok,
Joseph G. Jardine, ..., David Nemazee,
Dennis R. Burton, William R. Schief
Correspondence
[email protected] (D.N.),
[email protected] (D.R.B.),
[email protected] (W.R.S.)
In Brief
Development of boosting HIV envelope
immunogens designed to guide the
genetic and functional maturation of
VRC01-class bnAbs provides a roadmap
for the design of an effective HIV vaccine.
Data Resources
KX779470–KX779519
KX808478–KX808481
Briney et al., 2016, Cell 166 , 1459–1470
September 8, 2016ª2016 The Authors. Published by Elsevier Inc.
http://dx.doi.org/10.1016/j.cell.2016.08.005