Cell - 8 September 2016

Article

Tailored Immunogens Direct Affinity Maturation

toward HIV Neutralizing Antibodies

Graphical Abstract

Highlights

d Designed boosting immunogens to follow a VRC01-class

germline-targeting prime

d Boosted Abs selectively incorporate VRC01-class somatic

mutations

d Sequential boosts elicit VRC01-class mAbs with broad

neutralization of N276A viruses

d Vaccine-elicited VRC01-class mAbs neutralize one fully

native HIV isolate

Authors

Bryan Briney, Devin Sok,

Joseph G. Jardine, ..., David Nemazee,

Dennis R. Burton, William R. Schief

Correspondence

[email protected] (D.N.),

[email protected] (D.R.B.),

[email protected] (W.R.S.)

In Brief

Development of boosting HIV envelope

immunogens designed to guide the

genetic and functional maturation of

VRC01-class bnAbs provides a roadmap

for the design of an effective HIV vaccine.

Data Resources

KX779470–KX779519

KX808478–KX808481

Briney et al., 2016, Cell 166 , 1459–1470

September 8, 2016ª2016 The Authors. Published by Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.08.005