Cell - 8 September 2016

Article

gdT Cells Support Pancreatic Oncogenesis by

Restrainingab T Cell Activation

Graphical Abstract

Highlights

d gdT cells are highly prevalent in human pancreatic

carcinoma

d Deletion or interruption ofgdT cell recruitment is protective in

pancreatic cancer

d Pancreatic cancer infiltratinggdT cells express high levels of

checkpoint ligands

d gdT cells disableabT cell activation via checkpoint receptor

ligation

Authors

Donnele Daley,

Constantinos Pantelis Zambirinis,

Lena Seifert, ..., Dafna Bar-Sagi,

Cristina Hajdu, George Miller

Correspondence

[email protected]

In Brief

gdT cells are key regulators of effector

T cell activation in pancreatic cancer and

a new target for cancer immunotherapy.

Daley et al., 2016, Cell 166 , 1485–1499

September 8, 2016ª2016 Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.07.046