Cell - 8 September 2016

Article

Opposing Effects of Fasting Metabolism on Tissue

Tolerance in Bacterial and Viral Inflammation

Graphical Abstract

Highlights

d Fasting metabolism is protective in bacterial, but not viral,

inflammation

d Ketone bodies limit ROS-induced neuronal damage during

bacterial inflammation

d Glucose utilization prevents UPR-mediated neuronal

damage during viral inflammation

Authors

Andrew Wang, Sarah C. Huen,

Harding H. Luan, ...,

Jean-Dominique Gallezot,

Carmen J. Booth, Ruslan Medzhitov

Correspondence

[email protected]

In Brief

Starve a fever, stuff a cold: why anorexia

helps the organism to tolerate bacterial

infections but makes viral infections hard

to endure.

Wang et al., 2016, Cell 166 , 1512–1525

September 8, 2016ª2016 Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.07.026