Article
Neuroendocrine Coordination of Mitochondrial
Stress Signaling and Proteostasis
Graphical Abstract
Highlights
d Across species, poly-glutamine repeat proteins bind to and
influence mitochondria
d PolyQ and other neuronal mitochondrial stress induce a cell-
non-autonomous UPRmt
d UPRmtpathway components are required for sensing PolyQ-
induced neuronal stress
d Serotonin synthesis and secretion are required for non-
autonomous UPRmtinduction
Authors
Kristen M. Berendzen, Jenni Durieux,
Li-Wa Shao, ..., Suzanne Wolff, Ying Liu,
Andrew Dillin
Correspondence
[email protected]
In Brief
How is mitochondrial stress in the
nervous system signaled to other
tissues?
Berendzen et al., 2016, Cell 166 , 1553โ1563
September 8, 2016ยช2016 Elsevier Inc.
http://dx.doi.org/10.1016/j.cell.2016.08.042