Article
Dopamine Neuron-Specific Optogenetic Stimulation
in Rhesus Macaques
Graphical Abstract
Highlights
d Cell-type-specific promoter drives Cre-dependent ChR2
expression in monkey
d Optogenetically activated neurons had dopamine-like
features and reward responses
d Dopamine neurons respond strongly to cues predicting
optical stimulation
d Monkeys choose predicted optogenetic stimulation over no
predicted stimulation
Authors
William R. Stauffer, Armin Lak,
Aimei Yang, Melodie Borel, Ole Paulsen,
Edward S. Boyden, Wolfram Schultz
Correspondence
[email protected]
In Brief
Cell-type specific optogenetic
stimulation in Rhesus monkeys allows
manipulation of dopamine neurons to
demonstrate their role in reward-based
learning
Stauffer et al., 2016, Cell 166 , 1564โ1571
September 8, 2016ยช2016 The Authors. Published by Elsevier Inc.
http://dx.doi.org/10.1016/j.cell.2016.08.024