Resource
Development of a Comprehensive Genotype-to-
Fitness Map of Adaptation-Driving Mutations in
Yeast
Graphical Abstract
Highlights
d High-throughput method to survey adaptive mutations in
laboratory evolution
d Isolation of thousands of independent single adaptive events
genome-wide
d Bulk fitness measurements and genotyping generates a
genotype-to-fitness map
d Large sample size allows sensitive detection of fitness
differences even within genes
Authors
Sandeep Venkataram, Barbara Dunn,
Yuping Li, ..., Daniel S. Fisher,
Gavin Sherlock, Dmitri A. Petrov
Correspondence
[email protected] (G.S.),
[email protected] (D.A.P.)
In Brief
How can the entire suite of adaptive
mutations that occur in an evolving
population be pinpointed and each of
their fitness effects measured?
Venkataram et al., 2016, Cell 167 , 1585โ1596
September 8, 2016ยช2016 Elsevier Inc.
http://dx.doi.org/10.1016/j.cell.2016.08.002