Article
Structure of a Complete Mediator-RNA Polymerase II
Pre-Initiation Complex
Graphical Abstract
Highlights
d Isolation of a 52-protein, 2.5 MDa Mediator-RNA polymerase
II initiation complex
d Structural elucidation of the complex by cryo-EM and
chemical cross-linking
d Model for the regulation of CTD phosphorylation during
transcription initiation
d Mediator Tail module architecture and dynamics
Authors
Philip J. Robinson, Michael J. Trnka,
David A. Bushnell, Ralph E. Davis,
Pierre-Jean Mattei, Alma L. Burlingame,
Roger D. Kornberg
Correspondence
[email protected]
In Brief
Visualizing a complete Mediator-RNA
polymerase II pre-initiation complex
suggests a model explaining the basis for
control of transcription initiation by the
pol II C-terminal domain.
Robinson et al., 2016, Cell 166 , 1411โ1422
September 8, 2016ยช2016 Elsevier Inc.
http://dx.doi.org/10.1016/j.cell.2016.08.050