The Human Brain During the Third Trimester

Amygdaloid

glioepithelium/ependyma

Amygdaloid

glioepithelium/ependyma

FFrroonnttaall^ lloobbee

White matter

Cortical plate

Layer I

HYPO-

THALAMUS

HYPO-

THALAMUS

AMYGDAMYGDALAALA

BASAL

GANGLIA

BA SAL

GANGLIA

C

a

u

d

a

te

n

u

c

le

u

s (h

e

a

d

)

C

a

u

d

a

te

(^) n
u
c
le
u
s (h
e
a
d
)
TTe mporal lobeemporal lobe
Lateral
fissure
I
n
te
r
n
a
l
c
a
p
su
le
(^) (
a
n
te
ri
o
r
(^) l
im
b
)
I
n
te
r
n
a
l
c
a
p
su
le
(^) (
a
n
te
ri
o
r
(^) l
im
b
)
PutamenPutamen
Inferior frontal
gyrus
Inferior frontal
gyrus
Callosal glioepithelium
Fornix
glioepithelium?
Fo rnical
glioepithelium
Lateral migratory stream
(infiltrates claustrum and
penetrates insular cortex)
Lateral migratory stream
(infiltrates claustrum and
penetrates insular cortex)
Lateral migratory stream
(extends to amygdala)
Lateral migratory stream
(extends to amygdala)
Temporal neuroepithelium
and subventricular zone
Te mporal neuroepithelium
and subventricular zone
Lateral migratory stream
(extends to temporal neocortex)
Lateral migratory stream
(extends to temporal neocortex)
Ventral
striatum
Ve ntral
striatum
Induseum
griseum
Lateral
hypothalamic
area
Lateral
hypothalamic
area
D
o
rs
o
m
ed
ia
l
n
u
cl
eu
s
D
o
rs
o
m
ed
ia
l
n
u
cl
eu
s
Antero-
ventral
nucleus
Antero-
ventra l
nucleus
A
n
te
ro
m
ed
ia
l
nu
cl
eu
s
A
n
te
ro
m
ed
ia
l
nu
cl
eu
s

P

eri

v

entricular nuclei

P

eriventricular nuclei

V

en

tr

om

ed

ia

l

n

u

cl

eu

s

V

en

tr

om

ed

ia

l

n

u

cl

eu

s

Arcuate

nucleus

Arcuate

nucleus

G

lo

b

u

s^

p

a

llid

u

s

(in

te

rn

a

l

se

g

m

e

n

t)

G

lo

b

u

s^

p

a

llid

u

s

(in

te

rn

a

l

se

g

m

e

n

t)

G

lo

b

us pallidus

(exter

nal segm

ent)

G

lo

bu

s pallidus

(exter

nal segm

ent)

Cave of the septum

Stria

terminalis

Stria

terminalis

Uncinate

fasciculus

Uncinate

fasciculus

I

n

s

u

l

a r g y r u s

I

n

s

u

l

a r g y r u s

C

al

u

st

r

u

m

C

al

u

st

r

u

m

InterIntercalated massescalated masses

Basal nuc.

of Meynert

Basal nuc.

of Meynert

Medial

nucleus

Medial

nucleus

Central

nucleus

Central

nucleus

Basal

nucleus

Basal

nucleus

Lateral

nucleus

Lateral

nucleus

Cortical nucleiCortical nuclei

Abnormal

hemorrhage in the

germinal matrix

Abnormal

hemorrhage in the

germinal matrix

FFornixornix

F

or

ni

x

Fornix

Anterior

commissure

Anterior

commissure

CCoorrppuussccaalllloossuumm((bbooddyy))

O

pt

ic

(^) tr
ac
t

O

pt

ic

(^) tr
ac
t

E

x

t

e

r

n

a

l

c

a

p

us

el

E

x

t

e

r

n

a

l

c

a

p

us

el Stria

medullaris

Stria

medullaris

Subfornical

organ

Subfornical

organ

Third ventricle

Lateral ve ntricle

Medial

forebrain

bundle

Medial

fo rebrain

bundle

Ventral

anterior

nucleus

Ventral

anterior

nucleus

Mammilio-

thalamic

tract?

Mammilio-

thalamic

tract?

M

e

d

u

ll

ar

y

la

m

in

a

M

e

d

u

ll

ar

y

la

m

in

a

Ansale

nt

ic

u

la

ri

s

Ansale

nt

ic

u

la

ri

s

Subs

tant

iai

nn

om

in

ata

Subs

tant

iai

nn

om

in

ata

Choroid

plexus

Choroid

plexus

V

EN

TR

A

L

C

O

M

PL

EX

V

EN

TR

A

L

C

O

M

PL

EX

ANTERIOR

COMPLEX

ANTERIOR

COMPLEX

P

E

R

IV

E

N

T

R

I

C

U

L

A

R

C

O

M

P

L

E

X

P

E

R

IV

E

N

T

R

I

C

U

L

A

R

C

O

M

P

L

E

THALAMUSTHALAMUS X

Migratory waves

(from the lateral

migratory stream accumulate

in the lateral nucleus)

Migratory waves

(from the lateral

migratory stream accumulate

in the lateral nucleus)

R

e

ti

c

u

la

r

n

u

cl

eu

s

R

e

ti

c

u

la

r

n

u

cl

eu

s

R

E

T

IC

U

L

A

R

B

E

LT

R

E

T

IC

U

L

A

R

B

E

LT

Amygdalo-

hippocampal

area

Amygdalo-

hippocampal

area

Pa rahippocampal stra-

tified transitional field

Pa rahippocampal

neuroepithelium and

subventricular zone

Subpial granular layer

Choroid plexus

stem cells?

Choroid plexus

stem cells?

Foramen

of Monr

o

Foramen

of Monr

o

Anteromedial striatal neuroepithelium

and subventricular zone

Anteromedial striatal neuroepithelium

and subventricular zone

Strionuclear glioepitheliuStrionuclear glioepitheliumm

Germinal and transitional structures in italics

Inferior temporal

gyrus

Inferior temporal

gyrus

Fusiform

gyrus

Fusiform

gyrus

Middle temporal

gyrus

Middle temporal

gyrus

Superior temporal

gyrus

Superior temporal

gyrus

Hypothalamic

glioepithelium/

ependyma

Hypothalamic

glioepithelium/

ependyma

Thalamic

glioepithelium/

ependyma

Thalamic

glioepithelium/

ependyma

Entorhinal cortex

Parolfactory/

parahippocampal

gyrus

Parolfactory/

parahippocampal

gyrus

Callosal slingCallosal sling

PLATE 178B