Table 7.2A summary of marker expression profiles and known physiological functions of the more common surface antigen markers used to phenotype adipose-derived stromal cellsa
Surface protein markerAlternative name(s)Cells which express the proteinPhysiological functionsCD13Aminopeptidase N (APN)-^
Granulocytes-^
Interdigitating dendritic cells-^
Large granular lymphocyte subpopulation-^
Macrophages-^
Mast cells-^
Monocytes-^
Myelomonocytes-^
Osteoclasts-^
Others-^
Play a role in enzymatic degradation processesCD29-^
Glycoprotein IIa (GP IIa)-^
Integrin beta-1 (ITGB1)-^
Fibronectin receptor beta subunit-^
VLA (CD49) beta chain-^
Fibroblasts-^
Platelets-^
T cells-^
Monocytes-^
Granulocytes (low expression level)-^
Mast cells-^
Endothelial cells-^
Myoepithelium-^
Others-^
Receptor for collagen and laminin-^
Play a role in cell-to-cell adhesion-^
Play an important role in lymphocyte trafficking and transvascular migrationCD44-^
CD44s (standard isoform)-^
CD44H (lacks all alternative exons)-^
Expressed by the majority of mammalian cell types-^
A glycoprotein that plays a role in cell-cell interactions, cell adhesion and cell migration-^
Plays a role in the polar orientation of cells-^
Involved in leukocyte attachment and rolling on endothelial cellsCD73Ecto-5’-nucleotidase-^
B- and T-cell subpopulations-^
Endothelial cells-^
Follicular dendritic cells-^
Epithelial cells-^
Acts as a catalyst in the dephosphorylation of ribo- and deoxyribonucleotides to their corresponding nucleosides-^
Plays a role in lymphocyte adhesion to dendritic cells and endotheliumCD90Thy-1-^
Immature haematopoietic stem cells-^
Neurons-^
Activated endothelial cells-^
Fibroblasts-^
Potentially mediates the differentiation of haematopoietic stem cells-^
Plays a role in the adhesion of various leukocytes to activated endothelial cellsCD105Endoglin-^
Activated monocytes-^
Erythroid precursors in the bone marrow-^
Trophoblasts-^
Acts as a regulatory component of the TGF-beta receptor complex-^
Mediates cellular response to TGF-beta 1aInformation obtained from the PathologyOutlines.com website—http://www.pathologyoutlines.com/cdmarkers.html