Stem Cell Processing (Stem Cells in Clinical Applications)

167

Table 8.1

Benefi

ts and limitations of UCB SCBs (Abdullah

2011

; Ballen et al

.^2008

; Butler and Menitove

2011

; Guilcher et al

.^2014

; Sugarman et al

.^1997

;

Wagner et al

.^2013

; Yoder

2014)

Type of bank

Public

Hybrid

Private

Cost involved

Assumed by the bank and partially recovered from the recipient

A combination of public and private, with cross subsidization of the former by the latter

Borne by the donor

Cord blood owner

Bank

Bank or private donor

Private donor

Recipient

Unrelated transplant patients and researchers

Unrelated transplant patients, researchers, and private donors (donor or relative)

Donor or relative

Uses

Unrelated transplant and regenerative medicine (clinical trials and research)

Unrelated transplant and regenerative medicine (clinical trials, experimental treatments, and research)

Related transplant and regenerative medicine (experimental treatments)

Advantages

Unit available globally for a matching donor

Families can store units for personal use; may be made available to the public

Family has control over the stored unit

Stringent quality control of units

Publically donated units available globally for a matching donor

No cost implications for the donor

Private section subsidizes the public costs

Low CBU attrition rate

Disadvantages

Opportunity to donate is not universal due to stringent quality and testing criteria

Transferring the fi

nancial cost from public

subsidies like philanthropists and government to the private client is seen as a confl

ict of interests

Stored unit not available to public

High operating costs are diffi

cult to

manage

Donors often misinformed about the indications and effi

cacy of use

Product is not available for family

May be less stringent quality control Low retrieval rate Substantial fi

nancial cost to

families

8 Cord Blood Stem Cell Banking