86
iPSCs, such as hepatic cells, neuron cells, and myocardial cells, could be effectively
used for drug screening because of recapitulating salient disease features in vitro
(Chun et al. 2010 ).
A study by Mathur used iPSC-formed cardiomyocytes to construct 3D tissue to
mimic a minimal organoid structure of the heart. The authors applied this system to
test cardiac response to various drugs. The results showed that human iPSCs derived
from the cardiac microphysiological system could signifi cantly improve the ability
to predict drug toxicity in vitro (Mathur et al. 2015 ).
Fig. 4.3 Some strategies for iPSC production and application. IPSC could be produced from some
adult cells by transfection with lentiviral viruses, Sendai viruses, mRNA, or episomes of some
pluripotent factors. The obtained iPSCs could be used in drug screening, stem cell therapy, and
disease modeling
P.V. Pham et al.