479Di Talia S, She R, Blythe SA, Lu X, Zhang QF, Wieschaus EF (2013) Posttranslational control of
Cdc25 degradation terminates Drosophila’s early cell-cycle program. Curr Biol 23(2):127–132
Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM (2009) H2AX:
functional roles and potential applications. Chromosoma 118(6):683–692
Ducommun B, Brambilla P, Félix M, Franza BR, Karsenti E, Draetta G (1991) Cdc2 phosphoryla-
tion is required for its interaction with cyclin. EMBO J 10(11):3311–3319
Dunican DS, Ruzov A, Hackett JA, Meehan RR (2008) xDnmt1 regulates transcriptional silencing
in pre-MBT Xenopus embryos independently of its catalytic function. Development
135(7):1295–1302
Dworkin MB, Shrutkowski A, Dworkin-Rastl E (1985) Mobilization of specific maternal RNA
species into polysomes after fertilization in Xenopus laevis. Proc Natl Acad Sci U S A
82(22):7636–7640
Edgar BA, Datar SA (1996) Zygotic degradation of two maternal Cdc25 mRNAs terminates
Drosophila’s early cell cycle program. Genes Dev 10(15):1966–1977
Edgar BA, Kiehle CP, Schubiger G (1986) Cell cycle control by the nucleo-cytoplasmic ratio in
early Drosophila development. Cell 44(2):365–372
Edgar BA, O'Farrell PH (1989) Genetic control of cell division patterns in the Drosophila embryo.
Cell 57(1):177–187
Edgar BA, Schubiger G (1986) Parameters controlling transcriptional activation during early
Drosophila development. Cell 44(6):871–877
Edgar BA, Sprenger F, Duronio RJ, Leopold P, O'Farrell PH (1994) Distinct molecular mechanism
regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev
8(4):440–452
Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JW (1992) CDK2 encodes a
33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc
Natl Acad Sci U S A 89:2907–2911
Evans T, Rosenthal ET, Youngblom J, Distel D, Hunt T (1983) Cyclin: a protein specified by mater-
nal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33:389–396
Farrell JA, O'Farrell PH (2013) Mechanism and regulation of Cdc25/Twine protein destruction in
embryonic cell-cycle remodeling. Curr Biol 23(2):118–126
Farrell JA, O'Farrell PH (2014) From egg to gastrula: how the cell cycle is remodeled during the
Drosophila mid-blastula transition. Annu Rev Genet 48:269–294
Farrell JA, Shermoen AW, Yuan K, O'Farrell PH (2012) Embryonic onset of late replication
requires Cdc25 down-regulation. Genes Dev 26(7):714–725
Faure S, Lee MA, Keller T, ten Dijke P, Whitman M (2000) Endogenous patterns of TGFbeta
superfamily signaling during early Xenopus development. Development 127(13):2917–2931
Finkielstein CV, Lewellyn AL, Maller JL (2001) The midblastula transition in Xenopus embryos
activates multiple pathways to prevent apoptosis in response to DNA damage. Proc Natl Acad
Sci U S A 98:1006–1011
Flach G, Johnson MH, Braude PR, Taylor RA, Bolton VN (1982) The transition from maternal to
embryonic control in the 2-cell mouse embryo. EMBO J 1(6):681–686
Foygel K, Choi B, Jun S, Leong DE, Lee A, Wong CC, Zuo E, Eckart M, Reijo Pera RA, Wong
WH, Yao MW (2008) A novel and critical role for Oct4 as a regulator of the maternal-
embryonic transition. PLoS One 3(12):e4109
Frankenberg SR, Frank D, Harland R, Johnson AD, Nichols J, Niwa H, Scholer HR, Tanaka E, Wylie
C, Brickman JM (2014) The POU-er of gene nomenclature. Development 141(15):2921–2923
Freeman M, Glover DM (1987) The gnu mutation of Drosophila causes inappropriate DNA syn-
thesis in unfertilized and fertilized eggs. Genes Dev 1:924–930
Freeman M, Nusslein-Volhard C, Glover DM (1986) The dissociation of nuclear and centrosomal
division in gnu, a mutation causing giant nuclei in Drosophila. Cell 46(3):457–468
Gawlinski P, Nikolay R, Goursot C, Lawo S, Chaurasia B, Herz HM, Kussler-Schneider Y, Ruppert
T, Mayer M, Grosshans J (2007) The Drosophila mitotic inhibitor Fruhstart specifically binds
to the hydrophobic patch of cyclins. EMBO Rep 8(5):490–496
9 Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition