47Yoda A, Oda S, Shikano T, Kouchi Z, Awaji T, Shirakawa H, Kinoshita K, Miyazaki S (2004) Ca2+
oscillation-inducing phospholipase C zeta expressed in mouse eggs is accumulated to the pro-
nucleus during egg activation. Dev Biol 268:245–257. doi:10.1016/j.ydbio.2003.12.028
Yoneda A, Kashima M, Yoshida S, Terada K, Nakagawa S, Sakamoto A, Hayakawa K, Suzuki K,
Ueda J, Watanabe T (2006) Molecular cloning, testicular postnatal expression, and oocyte-
activating potential of porcine phospholipase Cζ. Reproduction 132:393–401. doi:10.1530/
rep.1.01018
Yoon SY, Fissore RA (2007) Release of phospholipase C ζ and [Ca2+]i oscillation-inducing activity
during mammalian fertilization. Reproduction 134:695–704. doi:10.1530/rep-07-0259
Yoon C, Kawakami K, Hopkins N (1997) Zebrafish vasa homologue RNA is localized to the cleavage
planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells.
Development 124:3157–3165
Yoon SY, Jellerette T, Salicioni AM, Lee HC, Yoo MS, Coward K, Parrington J, Grow D, Cibelli
JB, Visconti PE, Mager J, Fissore RA (2008) Human sperm devoid of PLC, zeta 1 fail to induce
Ca2+ release and are unable to initiate the first step of embryo development. J Clin Invest
118:3671–3681. doi:10.1172/JCI36942
Young C, Grasa P, Coward K, Davis LC, Parrington J (2009) Phospholipase C zeta undergoes
dynamic changes in its pattern of localization in sperm during capacitation and the acrosome
reaction. Fertil Steril 91:2230–2242. doi:10.1016/j.fertnstert.2008.05.021
Yu F, Sun L, Machaca K (2009) Orai1 internalization and STIM1 clustering inhibition modulate
SOCE inactivation during meiosis. Proc Natl Acad Sci U S A 106:17401–17406. doi:10.1073/
pnas.0904651106
Yu Y, Nomikos M, Theodoridou M, Nounesis G, Lai FA, Swann K (2012) PLCζ causes Ca2+ oscil-
lations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P. Mol Biol
Cell 23:371–380. doi:10.1091/mbc.E11-08-0687
Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan
MD (2006) Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+
release-activated Ca2+ channel activity. Proc Natl Acad Sci U S A 103:9357–9362. doi:10.1073/
pnas.0603161103
Zheng L, Krishnamoorthi R, Zolkiewski M, Wang X (2000) Distinct Ca2+ binding properties of
novel C2 domains of plant phospholipase Dα and β. J Biol Chem 275:19700–19706.
doi:10.1074/jbc.M001945200
1 Egg Activation at Fertilization