151
Wang K, Neumann H, Peak-Chew SY, Chin JW (2007a) Evolved orthogonal ribosomes enhance
the efficiency of synthetic genetic code expansion. Nat Biotechnol 25:770–777. doi:10.1038/
nbt1314
Wang W, Takimoto J, Louie G et al (2007b) Genetically encoding unnatural amino acids for cel-
lular and neuronal studies. Nat Neurosci 10:1063
Wang HH, Isaacs FJ, Carr PA et al (2009a) Programming cells by multiplex genome engineering
and accelerated evolution. Nature 460:894–898. doi:10.1038/nature08187
Wang Q, Parrish AR, Wang L (2009b) Expanding the genetic code for biological studies. Chem
Biol 16:323–336. doi:10.1016/j.chembiol.2009.03.001
Wang K, Sachdeva A, Cox DJ et al (2014) Optimized orthogonal translation of unnatural ami-
no acids enables spontaneous protein double-labelling and FRET. Nat Chem 6:393–403.
doi:10.1038/nchem.1919
Wu N, Deiters A, Cropp TA et al (2004) A genetically encoded photocaged amino acid. J Am Chem
Soc 126:14306–14307. doi:10.1021/ja040175z
Wu B, Chien EYT, Mol CD et al (2010) Structures of the CXCR4 chemokine GPCR with small-
molecule and cyclic peptide antagonists. Science 330:1066–1071. doi:10.1126/science.1194396
Xiu X, Puskar NL, Shanata JAP et al (2009) Nicotine binding to brain receptors requires a strong
cation-pi interaction. Nature 458:534–537. doi:10.1038/nature07768
Yamano K, Tanaka-Yamano S, Endo T (2010) Tom7 regulates Mdm10-mediated assembly of the
mitochondrial import channel protein Tom40. J Biol Chem 285:41222–41231. doi:10.1074/
jbc.M110.163238
Ye SX (2010) Tracking G-protein-coupled receptor activation using genetically encoded infrared
probes. Nature 464:1386–1389. doi:10.1038/nature08948
Ye SX, Huber T, Vogel R, Sakmar TP (2009) FTIR analysis of GPCR activation using azido
probes. Nat Chem Biol 5:397–399. doi:10.1038/nchembio.167
Ye S, Riou M, Carvalho S, Paoletti P (2013) Expanding the genetic code in Xenopus laevis oo-
cytes. Chembiochem Eur J Chem Biol 14:230–235. doi:10.1002/cbic.201200515
Young DD, Young TS, Jahnz M et al (2011) An evolved aminoacyl-tRNA synthetase with atypical
polysubstrate specificity. Biochemistry (Mosc) 50:1894–1900. doi:10.1021/bi101929e
Zacharias N, Dougherty DA (2002) Cation-pi interactions in ligand recognition and catalysis.
Trends Pharmacol Sci 23:281–287
Zhang Z, Wang L, Brock A, Schultz P (2002) The selective incorporation of alkenes into proteins
in Escherichia coli. Angew Chem Int Ed Engl 41:2840
Zhang Y, Wang L, Schultz PG, Wilson IA (2005) Crystal structures of apo wild-type M. jannaschii
tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine.
Protein Sci Publ Protein Soc 14:1340–1349. doi:10.1110/ps.041239305
Zhong W, Gallivan JP, Zhang Y et al (1998) From ab initio quantum mechanics to molecular
neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A
95:12088–12093
Incorporation of Non-Canonical Amino Acids