Novel Chemical Tools to Study Ion Channel Biology (Advances in Experimental Medicine and Biology)

(sharon) #1

84 K. Mruk and W. R. Kobertz


Tether

Targeting moieties

Ion channels

Application/Results

Refs.

PhotoreversibleAzobenzene

Glutamate

Maleimide

iGluR6, mGluR2, mGluR3, and mGluR6

Optogenetic control of ionotopic and metabotropic glutamate receptors

Volgraf et

al. (

2006

)

Levitz et

al. (

2013

)

Azobenzene

Acetylcholine homocholine

Maleimide

a4b2, a4b3, a4b4 nAChRs Optogenetic control of nico-

tinic acetylcholine receptors

Tochitsky et

al. (

2012

)

Azobenzene

Trimethylammonium Alkylbromide

nAChR

Kinetics of ligand-dependent opening and closing of receptors

Lester et

al (

1980

)

Azobenzene

Tetraethylammonim (TEA)

Maleimide

Shaker, Kv1.3, Kv3.2, Kv7.2, SK, and TREK

Optogenetic control of K+ channels

Banghart et

al. (

2004

)

Fortin et

al. (

2008

)

Sandoz et

al. (

2012

)

Table 1

(continued)
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