104 6 ART for Antiaging
Cerqueira FM, Laurindo FRM, Kowaltowski AJ (2011) Mild mitochondrial uncoupling and calo-
rie restriction increase fasting eNOS, akt and mitochondrial biogenesis. PLoS One 6:e18433
Chan SW, Blackburn EH (2002) New ways not to make ends meet: telomerase, DNA damage
proteins and heterochromatin. Oncogene 21:553–563
Chen ZP, Mitchelhill KI, Michell BJ, Stapleton D, Rodriguez-Crespo I, Witters LA, Power D,
Oritz de Montellano PR, Kemp BE (1999) AMP-activated protein kinase phosphorylation of
endothelial nitric oxide synthase. FEBS Lett 443:285–289
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS,
Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat
C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger
SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue
K, Jung ME, Frand AR, Huang J (2014) The metabolite α-ketoglutarate extends lifespan by
inhibiting ATP synthase and TOR. Nature 510:397–401
Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR,
Ravussin E, Pennington Team CALERIE (2007) CR increases muscle mitochondrial bio-
genesis in healthy humans. PLoS Med 4:e76
Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB,
Cruzen C, Simmons HA, Kemnitz JW, Weindruch R (2009) CR delays disease onset and
mortality in rhesus monkeys. Science 325:201–204
D’Antona G, Ragni M, Cardile A, Tedesco L, Dossena M, Bruttini F, Caliaro F, Corsetti R,
Carruba MO, Valerio A, Nisoli E (2010) Branched-chain amino acid supplementation pro-
motes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in mid-
dle-aged mice. Cell Metabol 12:362–372
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of
NOS in endothelial cells by Akt-dependent phosphorylation. Nature 399:601–605
Fabrizio P, Pozza SD, Pletcher CM, Gendron CM, Longo VD (2001) Regulation of longevity and
stress resistance by Sch9 in yeast. Science 292:288–290
Finocchietto P, Barreyro F, Holod S, Peralta J, Franco MC, Mendez C, Converso DP, Estevez A,
Carreras MC, Poderoso JJ (2008) Control of muscle mitochondria by insulin entails activa-
tion of Akt2-mtNOS pathway: implications for the metabolic syndrome. PLoS One 3:e1749
Fontana L, Klein S (2007) Aging, adiposity, and calorie restriction. JAMA 297:986–994
Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A,
Sessa WC (1999) Regulation of endothelium-derived nitric oxide production by the protein
kinase Akt. Nature 399:597–601
Gad MZ (2010) Anti-aging effects of L-arginine. J Adv Res 1:169–177
Gaitanaki C, Konstantina S, Chrysaand S, Beis I (2003) Oxidative stress stimulates multi-
ple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused
amphibian heart. J Exp Biol 206:2759–2769
Giulivi C, Poderoso JJ, Boveris A (1998) Production of nitric oxide by mitochondria. J Biol
Chem 273:11038–11043
Gustin MC, Albertyn J, Alexander M, Davenport K (1998) MAP kinase pathways in the yeast
Saccharomyces cerevisiae. Microbiol Mol Biol Rev 62:1264–1300
Hands SL, Proud CG, Wyttenbach A (2009) mTOR’s role in ageing: protein synthesis or
autophagy. Aging 1:586–597
Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C (2008) A role for autophagy
in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4:e24
Hancock CR, Han DH, Higashida K, Kim SH, Holloszy JO (2011) Does CR induce mitochon-
drial biogenesis? A reevaluation. FASEB J 25:785–791
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE,
Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA (2009) Rapamycin fed
late in life extends lifespan in genetically heterogeneous mice. Nature 460:392–395
Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, Ogataand H, Ohta T
(2001) The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast
cancer-derived mutation. J Biol Chem 276:14537–14540