v A left shift indicates increased O 2 affinity of Hb. This allows less O 2 to be available to the tissues.
v CO, Fetal Hb, Mycoglobin do not unload O 2 from Hb. So these cause a left shift in the curve.
Thus Bohr’s & Haldane’s effects complement each other.
v Addition of CO 2 to the blood at tissue site facilitates unloading of O 2 by Bohr’s effect.
v O 2 unloading inturn, favours CO 2 uptake by Haldane’s effect.
v