116 Obstetrics and Gynecology Board Review •••
❍ How long do you anticoagulate someone with antiphospholipid syndrome (APAS)?
Duration of their pregnancy and the 6 weeks postpartum.
❍ What type of birth control is contraindicated in someone with APAS?
Any estrogen containing birth control
❍ Who should be tested for inherited thrombophilias?
(1) Personal history of venous thromboembolism associated with a nonrecurrent risk factor (fractures, surgery,
prolonged immobilization).
(2) First-degree relative with a history of high-risk thrombophilia or venous thromboembolism before age 50.
❍ What tests should you order to screen on a patient for inherited thrombophilias?
(1) Factor V Leiden mutation.
(2) Prothrombin gene mutation.
(3) Protein C deficiency.
(4) Protein S deficiency.
(5) Antithrombin III deficiency.
❍ Which thrombophilia should not be screened for in pregnancy?
Protein S deficiency.
❍ What is the neonatal complication of protein C deficiency?
Neonatal purpura fulminans (requiring lifelong anticoagulation).