••• CHAPTER 33^ Menopause^337
❍ How should estrogen be administered to women with triglyceride levels between 250 and 750 mg/dL?
A nonoral route of estrogen with careful surveillance of triglyceride levels.
❍ How quickly do triglyceride levels increase after estrogen replacement administration?
Triglycerides increase quickly and can be measured between 2 and 4 weeks.
❍ What triglyceride levels are an absolute contraindication to estrogen therapy?
750 mg/dL.
❍ What effect does estrogen have on Alzheimer disease?
According to the NHS, Alzheimer disease is less frequent among HRT users, and cognitive function in affected
individuals is improved; however, in WHI dementia is more frequent in HRT and ET users entering the study
over age 65 although the difference is not statistically significant.