458 Obstetrics and Gynecology Board Review •••
❍ Serous low malignant potential tumors account for what percentage of all serous tumors?
Approximately 15%.
❍ Well-differentiated serous adenocarcinoma is histologically defined by?
A predominance of papillary and glandular cells, round to oval nuclei, and 0 to 2 mitoses per high-power field.
❍ Poorly differentiated serous adenocarcinoma is histologically defined by?
Solid sheets of cells, nuclear atypia, and 2 to 3 mitoses per high-power field.
❍ What percentage of mucinous tumors of the ovary are malignant?
<10%.
❍ Mucinous tumors histologically resemble what other cell type?
Mucinous tumors may resemble either endocervix or gastrointestinal tract.
❍ Which type of ovarian tumors are often associated with similar lesions in the endometrium?
Endometrioid.
❍ Which ovarian tumors are associated with endometriosis and histologically are composed of cells that
project their nuclei to the apical cytoplasm, known as hobnail cells?
Clear cell tumors.
❍ Clear cell tumors are often associated with which clinical/laboratory findings?
Hypercalcemia and hyperpyrexia.
❍ A similar constellation of clinical symptoms seen in patients with ovarian cancer is also associated with?
(1) Mesothelioma.
(2) Primary peritoneal carcinoma.
(3) Tuberculous peritonitis.
❍ This solid tumor type is associated with epithelioid cells that show a coffee bean pattern caused by
longitudinal grooving of the nuclei:
Brenner tumors.
❍ What is the lifetime risk of developing ovarian cancer in BRCA1 and BRCA2 carriers?
Women with BRCA1 mutations have a 40% to 50% risk of developing ovarian cancer, while women with BRCA2
mutations have a 10% to 25% risk.
❍ What hereditary syndromes of cancer have been associated with an increased risk of ovarian cancer?
(1) Site-specific familial ovarian cancer.
(2) Breast/ovarian familial cancer syndromes.
(3) Hereditary nonpolyposis colorectal cancer (HNPCC) (formerly known as Lynch II syndrome).