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Chapter 51 Gynecologic Pathology
Mitchell I. Edelson, MD
❍ What is the sex-determining region Y (SRY) gene?
The SRY gene is found in the 1A1 region at the distal end of chromosome Yp. Its presence dictates development of
testicles, while its absence results in ovarian differentiation.
❍ What two substances are responsible for development of the Wolffian duct system and regression of the
Müllerian ducts?
Testosterone and Müllerian-inhibiting substance (MIS) that are produced by the testes.
❍ What is a hermaphrodite?
The presence of both ovarian and testicular tissue in a single individual.
❍ What is the most common karyotype in Turner syndrome?
45X.
❍ What is the most common cause of male pseudohermaphroditism?
Androgen insensitivity syndrome (testicular feminization).
❍ What is the most common cause of ambiguous genitalia?
Congenital adrenal hyperplasia.
❍ What are the causative agents of granuloma inguinale and lymphogranuloma venereum?
Calymmatobacterium granulomatis and Chlamydia, respectively.
❍ What is the name of the cytology preparation whereby one scrapes the base of a fresh vesicle, spreads the
material on a slide, and stains it in an attempt to diagnose herpes?
Tzanck prep.