••• Chapter 52^ Hypothalamic-Pituitary-Ovarian-Uterine Axis^525
❍ What is the effect of a C-21 deficiency in females and males?
It causes pseudohermaphrodites in females and macrogenitosomia praecox (enlarged external genitalia) in males.
❍ What is the most classic symptom of androgen excess?
Hirsutism.
❍ What test would rule out congenital adrenal hyperplasia?
Failure of the dexamethasone suppression test.
❍ What is the treatment of congenital adrenal hyperplasia?
Glucocorticoid administration to suppress ACTH.
❍ What condition results from a G protein mutation that autonomously activates the LH receptor?
Precocious puberty in males.
❍ What condition results from a G protein mutation that autonomously inactivates the LH receptor?
Male pseudohermaphroditism.
❍ G protein mutation with resultant inactivation of FSH receptor results in?
Premature ovarian failure.