221
- Li C, Yu S, Nakamura F, Pentikainen OT, Singh N, Yin S, Xin W, Sy MS (2010) Pro-prion
binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanoma-
genesis. J Biol Chem 285:30328–30339 - Mange A, Milhavet O, Umlauf D, Harris D, Lehmann S (2002) PrP-dependent cell adhesion
in N2a neuroblastoma cells. FEBS Lett 514:159–162 - Kaneider NC, Kaser A, Dunzendorfer S, Tilg H, Patsch JR, Wiedermann CJ (2005)
Neurokinin-1 receptor interacts with PrP(106-126)-induced dendritic cell migration and
maturation. J Neuroimmunol 158:153–158 - Zhou H, Zhou X, Kouadir M, Zhang Z, Yin X, Yang L, Zhao D (2009) Induction of macro-
phage migration by neurotoxic prion protein fragment. J Neurosci Methods 181:1–5 - Tu J, Yang L, Zhou X, Qi K, Wang J, Kouadir M, Xu L, Yin X, Zhao D (2014) PrP106- 126 and
Abeta 1-42 peptides induce BV-2 microglia chemotaxis and proliferation. J Mol Neurosci:
MN 52:107–116 - Viegas P, Chaverot N, Enslen H, Perriere N, Couraud PO, Cazaubon S (2006) Junctional
expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial
migration of human monocytes. J Cell Sci 119:4634–4643 - Azzalin A, Sbalchiero E, Barbieri G, Palumbo S, Muzzini C, Comincini S (2008) The dop-
pel (Dpl) protein influences in vitro migration capability in astrocytoma-derived cells. Cell
Oncol: Off J Int Soc Cell Oncol 30:491–501 - Watanabe T, Yasutaka Y, Nishioku T, Kusakabe S, Futagami K, Yamauchi A, Kataoka Y
(2011) Involvement of the cellular prion protein in the migration of brain microvascular
endothelial cells. Neurosci Lett 496:121–124 - Mosesson Y, Mills GB, Yarden Y (2008) Derailed endocytosis: an emerging feature of cancer.
Nat Rev Cancer 8:835–850 - Green KJ, Getsios S, Troyanovsky S, Godsel LM (2010) Intercellular junction assembly,
dynamics, and homeostasis. Csh Perspect Biol 2 - Solis GP, Schrock Y, Hulsbusch N, Wiechers M, Plattner H, Stuermer CAO (2012) Reggies/
flotillins regulate E-cadherin-mediated cell contact formation by affecting EGFR trafficking.
Mol Biol Cell 23:1812–1825 - Du L, Rao G, Wang H, Li B, Tian W, Cui J, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu
Y, Tang DG, Mehrpour M, Lu Y, Chen Q (2013) CD44-positive cancer stem cells express-
ing cellular prion protein contribute to metastatic capacity in colorectal cancer. Cancer Res
73:2682–2694 - Cheng Y, Tao L, Xu J, Li Q, Yu J, Jin Y, Chen Q, Xu Z, Zou Q, Liu X (2014) CD44/cellular
prion protein interact in multidrug resistant breast cancer cells and correlate with responses
to neoadjuvant chemotherapy in breast cancer patients. Mol Carcinog 53:686–697 - Richardson DD, Tol S, Valle-Encinas E, Pleguezuelos C, Bierings R, Geerts D, Fernandez-
Borja M (2015) The prion protein inhibits monocytic cell migration by stimulating beta 1
integrin adhesion and uropod formation. J Cell Sci 128:3018–3029 - Caughey B, Brown K, Raymond GJ, Katzenstein GE, Thresher W (1994) Binding of the
protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red
[corrected]. J Virol 68:2135–2141 - Gao ZX, Zhang HX, Hu F, Yang LH, Yang XW, Zhu Y, Sy MS, Li CY (2016) Glycan-deficient
PrP stimulates VEGFR2 signaling via glycosaminoglycan. Cell Signal 28:652–662 - Li C, Yu S, Nakamura F, Yin S, Xu J, Petrolla AA, Singh N, Tartakoff A, Abbott DW, Xin W,
Sy MS (2009) Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with
poor prognosis in pancreatic cancer. J Clin Invest 119:2725–2736 - Yang LH, Gao ZX, Hu LP, Wu GR, Yang XW, Zhang LH, Zhu Y, Wong BS, Xin W, Sy
MS, Li CY (2016) Glycosylphosphatidylinositol anchor modification machinery deficiency
is responsible for the formation of pro-prion protein (PrP) in BxPC-3 protein and increases
cancer cell motility. J Biol Chem 291:3905–3917
13 Prion Protein Exacerbates Tumorigenesis