93References
Aardal S, Helle KB (1992) The vasoinhibitory activity of bovine chromogranin A fragment
(vasostatin) and its independence of extracellular calcium in isolated segments of human blood
vessels. Regul Pept 41(1):9–18
Angelone T, Quintieri AM, Goumon Y, Di Felice V, Filice E, Gattuso A, Mazza R, Corti A, Tota B,
Metz-Boutigue MH, Cerra MC (2010) Cytoskeleton mediates negative inotropism and lusitro-
pism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA(1-64)) in the rat
heart. Regul Pept 165(1):78–85
Bianco M, Gasparri AM, Colombo B, Curnis F, Girlanda S, Ponzoni M, Bertilaccio MT, Calcinotto
A, Sacchi A, Ferrero E, Ferrarini M, Chesi M, Bergsagel PL, Bellone M, Tonon G, Ciceri
F, Marcatti M, Caligaris Cappio F, Corti A (2016) Chromogranin A is preferentially cleaved
into pro-angiogenic peptides in the bone marrow of multiple myeloma patients. Cancer Res.
doi:10.1158/0008-5472.CAN-15-1637
Biswas N, Vaingankar SM, Mahata M, Das M, Gayen JR, Taupenot L, Torpey JW, O'Connor DT,
Mahata SK (2008) Proteolytic cleavage of human chromogranin a containing naturally occur-
ring catestatin variants: differential processing at catestatin region by plasmin. Endocrinology
149(2):749–757
Biswas N, Rodriguez-Flores JL, Courel M, Gayen JR, Vaingankar SM, Mahata M, Torpey JW,
Taupenot L, O’Connor DT, Mahata SK (2009) Cathepsin L colocalizes with chromogranin a in
chromaffin vesicles to generate active peptides. Endocrinology 150(8):3547–3557
Biswas N, Curello E, O'Connor DT, Mahata SK (2010) Chromogranin/secretogranin proteins in
murine heart: myocardial production of chromogranin A fragment catestatin (Chga(364-384)).
Cell Tissue Res 342(3):353–361. doi:10.1007/s00441-010-1059-4
Blois A, Srebro B, Mandalà M, Corti A, Helle KB, Serck-Hanssen G (2006a) The chromogranin
A peptide vasostatin-I inhibits gap formation and signal transduction mediated by inflamma-
tory agents in cultured bovine pulmonary and coronary arterial endothelial cells. Regul Pept
135:78–84
Blois A, Holmsen H, Martino G, Corti A, Metz-Boutigue MH, Helle KB (2006b) Interactions of
chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcho-
line and phosphatidylethanolamine. Regul Pept 134(1):30–37
Borch K, Stridsberg M, Burman P, Rehfeld JF (1997) Basal chromogranin A and gastrin con-
centrations in circulation correlate to endocrine cell proliferation in type-A gastritis. Scand
J Gastroenterol 32(3):198–202
Bretscher A, Edwards K, Fehon RG (2002) ERM proteins and merlin: integrators at the cell cortex.
Nature Reviews in Molecular and Cellular Biology 3(8):586–599
Castoldi G, Antolini L, Bombardi C, Perego L, Mariani P, Vigano MR, Torti G, Casati M, Corti A,
Zerbini G, Valsecchi MG, Stella A (2010) Oxidative stress biomarkers and chromogranin A in
uremic patients: effects of dialytic treatment. Clin Biochem 43(18):1387–1392. doi:10.1016/j.
clinbiochem.2010.08.028
Ceconi C, Ferrari R, Bachetti T, Opasich C, Volterrani M, Colombo B, Parrinello G, Corti A (2002)
Chromogranin A in heart failure; a novel neurohumoral factor and a predictor for mortality. Eur
Heart J 23(12):967–974
Ciesielski-Treska J, Ulrich G, Taupenot L, Chasserot-Golaz S, Corti A, Aunis D, Bader MF
(1998) Chromogranin A induces a neurotoxic phenotype in brain microglial cells. J Biol Chem
273(23):14339–14346
Colombo B, Longhi R, Marinzi C, Magni F, Cattaneo A, Yoo SH, Curnis F, Corti A (2002a)
Cleavage of chromogranin A N-terminal domain by plasmin provides a new mechanism for
regulating cell adhesion. J Biol Chem 277(48):45911–45919
Colombo B, Curnis F, Foglieni C, Monno A, Arrigoni G, Corti A (2002b) Chromogranin a expres-
sion in neoplastic cells affects tumor growth and morphogenesis in mouse models. Cancer Res
62(3):941–946
Chromogranin A in Endothelial Homeostasis and Angiogenesis