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CgA(1–400) and CgA(1–409) which is CgA minus the serpinin sequence].
However, the CgA C-terminal peptides, (serpinin, pGlu-serpinin and serpinin-
RRG), all reduced the number of new capillaries in the chick embryos induced by
bFGF in a dose dependent manner (Fig. 12B) (Crippa et al. 2013 ). Interestingly,
serpinin-RRG at 5 nM concentration was much more effective than serpinin and
pGlu-serpinin, and the dose response was bimodal, which often occurs with pep-
tides (Ojaniemi and Vuori 1997 ).
Fig. 12 Serpinin peptides exhibit anti-angiogenic activity. (A) The number of new capillaries
induced in chick embryos by bFGF were unaffected by C-terminally truncated forms of hCgA
(hCgA(1–373), hCgA(1–400) and hCgA(1–409)). (B) The hCgA C-terminal peptides, (serpinin,
pGlu-serpinin and serpinin-RRG), all reduced the number of new capillaries in the chick embryos
induced by bFGF in a dose dependent manner. Note that serpinin-RRG was more effective than
serpinin and pGlu-serpinin (From Crippa et al. 2013 )
Y. PengfiLoh et al.