64
9 General Conclusion
This review summarizes data concerning the processing of CGA and the biological
roles of the antimicrobial CGA-derived peptides. For two peptides VS-I and CAT,
we have characterized the active sequences (CHR, CTL) and their effects in pres-
ence of administered antibiotics. We demonstrated that CTL resists to bacterial pro-
teases. Several peptides might allow the decrease of the antibiotics concentrations
prescribed by clinicians.
The clinical studies show that high concentration of CGA in plasma with sepsis
and SIRS correlated with markers of inflammation. In addition, by using a combina-
tion of VS-I, lactate and age values, the assessment of prognosis was improved than
taking each parameter alone. This data is important to improve emergency triage in
patients with increased lactate levels without clinical signs of severity.
CTL, the active domain of CAT, was used to elaborate new self-defensive material
against S. aureus and C. albicans, two pathogens responsible of nosocomial infections.
Interestingly, the limited fibroblast adhesion, without cytotoxicity highlights a medi-
cally relevant application to prevent infections on catheters or tracheal prosthesis.
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