Multiphase Bioreactor Design

membrane. As a consequence of this barrier, the permeate flow rate also decreases,
although the situation reached an equilibrium.

Table 7.3 Rejection coefficients after stabilisation

of concentrations (24 h)

Solute σobs×100 (%)

protein 27 (or 94 if σreal×100 (%))*

water 17

Surfactant (AOT) 17

butanol 19

hexanol 17

butyl acetate 7

hexyl acetate 6

Enzyme membrane bioreactors can either be dead-end stirred cells (DESC) or crossflow
systems. The latter is much more efficient to control the effects of flux reduction than the
former.

Operation of enzyme micellar reactors in a batch mode

Modeling of a batch enzyme reactor

The design equation of a batch enzyme reactor for a reversible reaction is

(26)

The kinetic parameters for both substrates and products are used to model the MBR with
total recirculation as a batch reactor.

Determination of the single-pass conversion in the MBR operating in a

total recirculation operation mode

The overall substrate conversion, X, is given by:

(27)

and the substrate conversion per pass (corresponding to one passage through the
membrane), Xn, in a recirculated reactor is:

Reversed micellar bioreaction systems 215