In our comparison we did the simulations for batch operations:
Substrate is circulated until a certain amount of substrate is converted. In a
two-phase fluidised bed substrate is not totally converted due to product
inhibition. When the product concentration reaches the toxic product
concentration in the medium phase, the conversion stops. At this moment,
the product concentration inside the gel bead and in the medium phase are
the same and equal to the toxic product concentration.Figure 12.10 Profile of substrate (10a)
and product (10b) concentration in the
medium phase at different distribution
coefficients. Profile of product
concentration in the dodecane phase
(l0c) at different distribution
coefficients.
Uc=1.29 cm/s, Ud=0.91 cm/s, εs=0.32,
εo=0.0925; Xvmax=0.01 mol/m
3s,
=10 mol/m
3Figure 12.11 Profile of substrate (11a)
and product (11b) concentration in the
medium phase at different toxic
product concentrations. Profile of
product concentration in the dodecane
phase (11c) at different toxic product
concentrations.
Design of liquid-liquid-solid fluidised-bed bioreactors 371