Multiphase Bioreactor Design

dodecane hold-up is higher for a higher dodecane flux. Hence, the distribution coefficient
has to be higher for the higher dodecane fluxes.
The open symbols in Figure 12.13a and c show the distribution coefficient as a
function of the X·vmax for which the three-phase fluidised bed performs equally well for a
low toxic product concentration (1 mol/m^3 , i.e. 0.1% of the initial substrate
concentration). At the

Figure 12.13c Distribution coefficient

as a function of the maximum substrate

conversion for which a three-phase

fluidised bed performs equally well as

a liquid fluidised bed. Uc=2 cm/s, Ud

=0.14 cm/s Ud=0.28 cm/s Ud=0.54

cm/s. Open symbols=1 mol/m

3

,

closed symbols =100 mol/m

3

X vmax (mol/m^3 s) tbatch(99%) (min) =1 mol/m^3 =100 mol/m (^3)
0.001 355.8 32504
0.01 55.31 3278
0.05 23.81 699
0.1 19.63 361.4
1 17.02 55.94

Table 12.4 Distribution coefficients for different

liquid-liquid two-phase systems

Solute Two-phase
system

Distribution

coefficient

Reference

Multiphase bioreactor design 376