Keßler, M., ten Hoopen, H.J.G. and Furusaki, S. (1999) The effect of aggregate size on the
production of ajmalicine and tryptamine in Catharanthus roseus suspension culture. Enzyme
and Microbial Technology, 24, 308–315.
Ketchum, R.E.B., Gibson, D.M., Croteau, R.B. and Shuler, M.L. (1999) The kinetics of taxoid
accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate.
Biotechnology and Bioengineering, 62, 97–105.
Kieran, P.M., Malone, D.M. and MacLoughlin, P.P. (1993) Variation of aggregate size in plant cell
suspension batch and semi-continuous cultures. Food and BioProducts Processing, Trans. I.
Chem. E. (C), 71, 40–46.
Kieran, P.M., O’Donnell. H.J., Malone, D.M. and MacLoughlin, P.P. (1995) Fluid shear effects on
suspension cultures of Morinda citrifolia. Biotechnology and Bioengineering, 45, 415–425.
Kieran, P.M., P.F. MacLoughlin and D.M. Malone (1997) Plant cell suspension cultures—some
engineering considerations, Journal of Biotechnology, 59, 39–52.
Kieran, P.M., MacLoughlin, P.F. and Malone, D.M. (2000) Effects of hydrodynamic and interfacial
forces on plant cell suspension systems. Advances in Biochemical Engineering and
Biotechnology, 67, 139–177.
Kim, D.-I., Pedersen, H. and Chin, C.-K. (1991) Cultivation of Thalictrum rugosum cell suspension
in an improved airlift bioreactor: Stimulatory effect of carbon dioxide and ethylene on alkaloid
production. Biotechnology and Bioengineering, 38, 331–339.
Kobayashi, Y., Fukui, H. and Tabata, M. (1991) Effect of CO 2 and ethylene on berberine
production and cell browning in Thalictrum minus cell cultures. Plant Cell Reports, 9, 496–499.
Kobayashi, Y. et al. (1993) Large-scale production of anthocyanin by Aralia cordata cell
suspension cultures. Applied Microbiology and Biotechnology, 40, 215–218.
Koloini, T. (1990) Heat and mass transfer in industrial fermentation systems. Progress in
Biotechnology, 6, 215–239.
Leckie, F., Scragg, A.M. and Cliffe, K.C. (1991a) An investigation into the role of initial kLa on the
growth and alkaloid accumulation by cultures of Catharanthus roseus. Biotechnology and
Bioengineering, 37, 364–370.
Leckie, F., Scragg, A.H. and Cliffe, K.C. (1991b) Effect of impeller design and speed on the large
scale cultivation of suspension cultures of Catharanthus roseus. Enzyme and Microbial
Technology, 13, 801–810.
Li, G.-Q., Shin, J.H. and Lee, J.M. (1995) Mineral oil addition as a means of foam control for plant
cell cultures in stirred tank fermenters. Biotechnology Letters, 9, 713–718.
MacLoughlin, P.F., Malone, D.M., Murtagh, J.T. and Kieran, P.M. (1998) The effects of turbulent
jet flows on plant cell suspension cultures. Biotechnology and Bioengineering, 58, 595–604.
Madhusudan, R. and Ravishankar, G.A. (1996) Gradient of anthocyanin in cell aggregates of
Daucus carota in suspension cultures. Biotechnology Letters, 18, 1253–1256.
Matsubara, K., Kitani, S., Yoshioka, T., Morimoto, T. and Fujita, Y. (1989) High density culture of
Coptis japonica cells increases berberine production. Journal of Chemical Technology and
Biotechnology, 46, 61–69.
Matsubara, K. and Fujita, Y. (1991) Production of berberine. In Plant Cell Culture in Japan, edited
by A.Komamine, M.Misawa and F.DiCosmo, pp. 39–44. Tokyo: CMC.
Meijer, J.J. (1989) Effects of hydrodynamic and chemical/osmotic stress on plant cells a stirred
bioreactor. Ph.D. Thesis. Technical University of Delft, Delft, The Netherlands.
Meijer, J.J., ten Hoopen, H.J.G., Luyben, K.Ch.A.M. and Libbenga, K.R. (1993) Effects of
hydrodynamic stress on cultured plant cells: A literature survey. Enzyme and Microbial
Technology, 15, 234–238.
Meijer, J.J., ten Hoopen, H.J.G., van Gameren, Y.M., Luyben, K.Ch.A.M. and Libbenga, K.R.
(1994) Effects of hydrodynamic stress on the growth of plant cells in batch and continuous
culture. Enzyme and Microbial Technology, 16, 467–477.
Mirjalili, N. and Linden, J.C. (1995) Gas phase composition effects on suspension cultures of
Taxus cuspidata. Biotechnology and Bioengineering, 48, 123–132.
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