Table 12.1
(continued)
Location
# patients in study
Route of exposure
Clinical presentation
Allergens (molecularweights)
Reference
Milwaukee,WI (USA)
28
Smoking moldcontaminated marijuana
Mostly asymptomatic,some withbronchospasm
N/A
(Kagen et al.
1982
)
Valladolid,Spain
140 total with 53.2%patients positive forCannabis
skin prick test
and 34.3% patientspositive for speci
fic IgE
General allergic patientsand drug-dependentusers
Asthma, urticaria,rhinitis andanaphylaxis in somecases
N/A
(Armentia et al. 2011
)
Benidorm,Tres CantosandOrihuela,Spain
32 patients atopic totomato including 10 withallergic reactions toCannabis
exposure
Tomato-sensitizedpatients with contact orinhalation exposure toCannabis
Urticaria,rhinoconjunctivitis,itching and in somecases asthma-likesymptoms andpalpebral angioedema
9 –
10, 14, 30
- 35, 45
(de Larramendiet al.
2007
,^2008
)
Multi-centerstudy, Spain
44 patients tested positivefor
C. sativa
Smoking and handlingof
C. sativa
Broad respiratory andcutaneous symptomswith sporadic cases ofanaphylaxis
10 and 14 kDa(LTP) and 38 kDa(thaumatin-like protein)
(Larramendi et al. 2013
)
Toronto,Canada
17
Smoking and contactexposure. One patientconsumed marijuana tea
Rhinitis, conjunctivitis,sinusitis, wheezing,contact urticaria withperiorbital angioedemaand abdominalcramping in few cases
Major immunoreactivebands at 50 and 23identi
fied as RuBisCO
and OEP2 respectively.Other minor allergensranged from 10 to100 kDa.
(Nayak et al.
2013
;
Tessmer et al. 2012
)
Bakers
field,
CA (USA)
1
Intravenous personalexposure
Facial edema, pruritus,wheezing and dyspnea
N/A
(Perez
2000
)
(continued)
12 Allergenicity toCannabis sativaL.... 267