It is evident that the average distance between the THCAS sequences is much
lower (i.e. they are more similar) compared to CBDAS sequences, as already
reported by Onofri et al. ( 2015 ). The picture emerging from these observations
seems to indicate CBDAS sequences as the ancestors, with higher variability and
presence of pseudogenes, but clearly to develop a definitive view on the phylogeny
of this gene family, further data on sequences inCannabisgermplasm from dif-
ferent geographic origin need to be accumulated.
Fig. 15.5 Relationships between the THCAS and CBDAS published in the database as nucleotide
sequences. Only full-length sequences are represented
15 Genomics and Molecular Markers inCannabis sativaL. 337