Pertwee RG (2004) Pharmacological and therapeutic targets forD^9 -tetrahydrocannabinol and
cannabidiol. Euphytica 140:73– 82
Raboy V (2007) The ABCs of low-phytate crops. Nat Biotechnol 25:874– 875
Raharjo TJ, Chang WT, Verberne MC, Peltenburg-Looman AM, Linthorst HJ, Verpoorte R (2004)
Cloning and over-expression of a cDNA encoding a polyketide synthase fromCannabis sativa.
Plant Physiol Biochem 42:291– 297
Ranalli P, Venturi G (2004) Hemp as a raw material for industrial applications. Euphytica 140:1– 6
Rehm J, Fischer B (2015) Cannabis legalization with strict regulation, the overall superior policy
option for public health. Clin Pharmacol Ther 97:541– 544
Richez-Dumanois C, Braut-Boucher F, Cosson L, Paris M (1986) Multiplication végétative
in vitrodu chanvre (Cannabis sativaL.). Applicationàla conservation des clones sélectionnés.
Agronomie 6:487– 495
Ron M, Kajala K, Pauluzzi G, Wang D, Reynoso MA, Zumstein K, Garcha J, Winte S, Masson H,
Inagaki S, Federici F, Sinha N, Deal RB, Bailey-Serres J, Brady SM (2014) Hairy root
transformation usingAgrobacterium rhizogenesas a tool for exploring cell type-specific gene
expression and function using tomato as a model. Plant Physiol 166:455– 469
Salentijn EMJ, Zhang Q, Amaducci S, Yang M, Trindade LM (2015) New developments infiber
hemp (Cannabis sativaL.) breeding. Ind Crop Prod 68:32– 41
Shahzad A (2012) Hempfiber and its composites—a review. J Compos Mater 46:973– 986
Shi J, Wang H, Schellin K, Li B, Faller M, Stoop JM, Meeley RB, Ertl DS, Ranch JP, Glassman K
(2007) Embryo-specific silencing of a transporter reduces phytic acid content of maize and
soybean seeds. Nat Biotechnol 25:930– 937
Shi G, Liu C, Cui M, Ma Y, Cai Q (2012) Cadmium tolerance and bioaccumulation of 18 hemp
accessions. Appl Biochem Biotech 168:163– 173
Singh OV, Jain RK (2003) Phytoremediation of toxic aromatic pollutants from soil. Appl
Microbiol Biot 63:128– 135
Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F (2004)
The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression
ofD^1 -tetrahydrocannabinolic acid synthase fromCannabis sativaL. J Biol Chem 279:39767–
39774
Sirikantaramas S, Taura F, Tanaka Y, Ishikawa Y, Morimoto S, Shoyama Y (2005)
Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is
secreted into the storage cavity of the glandular trichomes. Plant Cell Physiol 46:1578– 1582
Slusarkiewicz-Jarzina A, Ponitka A, Kaczmarek Z (2005) Influence of cultivar, explant source and
plant growth regulator on callus induction and plant regeneration ofCannabis sativaL. Acta
Biol Crac Ser Bot 47:145– 151
Sparkes IA, Runions J, Kearns A, Hawes C (2006) Rapid, transient expression offluorescent
fusion proteins in tobacco plants and generation of stably transformed plants. Nat Protoc
1:2019– 2025
Spithoff S, Emerson B, Spithoff A (2015) Cannabis legalization: adhering to public health best
practice. Can Med Assoc J 187:1211– 1216
Srivastava S, Srivastava AK (2007) Hairy root culture for mass-production of high-value
secondary metabolites. Crit Rev Biotechnol 27:29– 43
Stott CG, Guy GW (2004) Cannabinoids for the pharmaceutical industry. Euphytica 140:83– 93
Stout JM, Boubakir Z, Ambrose SJ, Purves RW, Page JE (2012) The hexanoyl-CoA precursor for
cannabinoid biosynthesis is formed by an acyl-activating enzyme inCannabis sativa
trichomes. Plant J 71:353– 365
Sun X, Hu Z, Chen R, Jiang Q, Song G, Zhang H, Xi Y (2015) Targeted mutagenesis in soybean
using the CRISPR-Cas9 system. Sci Rep 5:10342
Taura F (2009) Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor
of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana. Drug Discov
Ther 3:83– 87
362 M. Feeney and Z.K. Punja