- Webb BA, Chimenti M, Jacobson MP, Barber
DL (2011) Dysregulated pH: a perfect storm
for cancer progression. Nat Rev Cancer 11
(9):671–677 - Sergeeva TS, Shirmanova MV, Zlobovskaya
OA, Gavrina AI, Dudenkova VV, Lukina
MM, Lukyanov KA, Zagaynova EV (2017)
Relationship between intracellular pH, meta-
bolic co-factors and caspase-3 activation in
cancer cells during apoptosis. Biochim Bio-
phys Acta. https://doi.org/10.1016/j.
bbamcr.2016.12.022 - Schwartza L, Seyfried T, Alfarouk KO, Mor-
eira JV, Fais S (2017) Out of Warburg effect:
an effective cancer treatment targeting the
tumor specific metabolism and dysregulated
pH. Semin Cancer Biol.https://doi.org/10.
1016/j.semcancer.2017.01.005 - Harguindey S, Stanciu D, Devesa J,
Alfarouk K, Cardone RA, Polo Orozco JD,
Devesa P, Rauch C, Orive G, Anitua E,
Roger S, Reshkin SJ (2017) Cellular acidifica-
tion as a new approach to cancer treatment
and to the understanding and therapeutics of
neurodegenerative diseases. Semin Cancer
Biol. https://doi.org/10.1016/j.semcancer.
2017.02.003 - Swietach P, Vaughan-Jones RD, Harris AL,
Hulikova A (2014) The chemistry, physiology
and pathology of pH in cancer. Philos Trans R
Soc B 329:1–9 - Harguindey S, Oriveb G, Pedra ́z JL, Paradiso
JA, Reshkind SJ (2005) The role of pH
dynamics and the Naþ/Hþ antiporter in
the etiopathogenesis and treatment of cancer.
Two faces of the same coin—one single
nature. Biochim Biophys Acta 1756:1–24 - Reshkin SJ, Bellizzi A, Caldeira S, Albarani V,
Malanchi I, Poignee M (2000) Naþ/Hþ
exchanger-dependent intracellular alkaliniza-
tion is an early event in malignant transforma-
tion and plays an essential role in the
development of subsequent transformation-
associated phenotypes. FASEB J
14:2185–2197 - Abaza MY, Luqmani A (2013) The influence
of pH and hypoxia on tumor metastasis.
Autophagy 13(10):1229–1242 - Link C (2011) Aerobic glycolysis: meeting
the metabolic requirements of cell prolifera-
tion. Cancer 27:441–464 - Vicent EE, Sergushichev A, Griss T et al
(2016) Mitochondrial phosphoenolpyruvate
carboxykinase regulates metabolic adaptation
and enables glucose-independent tumor
growth. Mol Cell 60:195–207
134. Gatenby RA, Gillies RJ (2007) Glycolysis in
cancer: a potential target for therapy. Int J
Biochem Cell Biol 39(7):1358–1366
135. Lucia U (2013) Thermodynamics and cancer
stationary states. Physica A 392:3648–3653
136. Lucia U (2014) Transport processes in
biological systems: tumoral cells and human
brain. Physica A 393:327–336
137. Lucı ́a U (2014) Transport processes and irre-
versible thermodynamics analysis in tumoral
systems. Physica A 410:380–390
138. Lucia U, Ponzetto A, Deisboeck TS (2016)
Investigating the impact of electromagnetic
fields on human cells: a thermodynamic per-
spective. Physica A 443:42–48
139. Lucia U, Ponzetto A, Deisboeck TS (2015) A
thermodynamic approach to the ‘mitosis/
apoptosis’ ratio in cancer. Physica A
436:246–255
140. Marı ́n-Herna ́ndez A, Lo ́pez-Ramı ́rez SY, Del
Mazo-Monsalvo I, Gallardo-Pe ́rez JC, Rodrı ́-
guez-Enrı ́quez S, Moreno-Sa ́nchez R, Saave-
dra E (2014) Modeling cancer glycolysis
under hypoglicemia, and the role played by
the differential expression of glycolytic iso-
forms. FEBS J 281:3325–3345
141. Montero S, Dura ́n I, Pomuceno-Ordun ̃ez JP,
Martin RR, Mesa MD, Mansilla R, Cocho G,
Nieto-Villar JM (2017) How much damage
can make the glucose in cancer? J Tumor Res
3(1):116
142. Bryant KL, Mancias JD, Kimmelman AC, Der
CJ (2014) KRAS: feeding pancreatic cancer
proliferation. Trends Biochem Sci 39
(2):91–100
143. Yun J, Rago C, Cheong I, Pagliarini R,
Angenendt P, Rajagopalan H, Schmidt K
(2009) Glucose deprivation contributes to
the development of KRAS pathway mutations
in tumor cells. Science 325:1555–1559
144. Manda G, Nechifor MT, Neagu TM (2009)
Reactive oxygen species, cancer and anti-
cancer therapies. Curr Chem Biol 3:342–366
145. Iglesias PA, Ingalls BP (2010) Control theory
and systems biology. The MIT Press, Cam-
bridge, MA
146. Goldbeter A (1997) Biochemical oscillations
and cellular rhythms: the molecular bases of
periodic and chaotic behaviour. Cambridge
University Press, Cambridge
147. Potter VR, Gebert RA, Pitot HC, Peraino C,
Lamar C Jr, Lesher S, Morris HP (1966)
Systematic oscillations in metabolic activity
in rat liver and in hepatomas I. Morris Hepa-
toma No. 7793. Cancer Res 26
(1):1547–1560
Parameters Estimation in Phase-Space Landscape Reconstruction of Cell Fate... 169