- Piras V, Hayashi K, Tomita M, Selvarajoo K
(2011) Enhancing apoptosis in TRAIL-
resistant cancer cells using fundamental
response rules. Sci Rep 1:144 - Hayashi K, Tabata S, Piras V, Tomita M, Sel-
varajoo K (2015) Systems biology strategy
reveals PKCδ is key for sensitizing TRAIL-
resistant human fibrosarcoma. Front Immunol
5:659 - Selvarajoo K (2017) A systems biology
approach to overcome TRAIL resistance in
cancer treatment. Prog Biophys Mol Biol
128:142–154 - Selvarajoo K, Tomita M, Tsuchiya M (2009)
Can complex cellular processes be governed by
simple linear rules? J Bioinformatics Comp Biol
7:243–268 - Selvarajoo K (2014) Parameter-less approaches
for interpreting dynamic cellular response. J
Biol Eng 8:23 - Kaufmann S (1995) At home in the universe:
the search for laws of self-organization and
complexity. Oxford University Press, New York - Chatterjee A, Cook LC, Shu CC, Chen Y,
Manias DA, Ramkrishna D et al (2013) Antag-
onistic self-sensing and mate-sensing signaling
controls antibiotic-resistance transfer. Proc
Natl Acad Sci U S A 110:7086–7090 - Poulsen AK, Lauritsen FR, Olsen LF (2004)
Sustained glycolytic oscillations—no need for
cyanide. FEMS Microbiol Lett 236:261–266 - Prigogine I (1997) The end of certainty. The
Free Press, New York - Field RJ, Koro ̈s E, Noyes RM (1972) Oscilla-
tions in chemical systems. II. Thorough analy-
sis of temporal oscillation in the bromate-
cerium-malonic acid system. J Am Chem Soc
94:8649–8664 - Epstein IR (2006) Predicting complex biology
with simple chemistry. Proc Natl Acad Sci U S
A 103:15727–15728 - Richard JF, Noyes RM (1974) Oscillations in
chemical systems. IV. Limit cycle behavior in a
model of a real chemical reaction. J Chem Phys
60:1877–1884 - Goodwin BC (1965) Oscillatory behaviour in
enzymatic control processes. Adv Enz Reg
3:425–428 - Ruoff P, Vinsjevik M, Monnerjahn C, Rensing
L (1999) The Goodwin oscillator: on the
importance of degradation reactions in the cir-
cadian clock. J Biol Rhythm 14:469–479 - Franc ̧ois P, Despierre N, Siggia E (2012) Adap-
tive temperature compensation in circadian
oscillations. PLoS Comput Biol 8:e1002585 - Zeiser S, Muller J, Liebscher V (2007) Model-
ing the Hes1 oscillator. J Comput Biol
14:984–1000
31. Griffith JS (1968) Mathematics of cellular con-
trol processes. I. Negative feedback to one
gene. J Theor Biol 20:202–208
32. Elowitz MB, Leibler S (2000) A synthetic oscil-
latory network of transcriptional regulators.
Nature 403:335–338
33. Gardner TS, Cantor CR, Collins JJ (2000)
Construction of a genetic toggle switch in
Escherichia coli. Nature 403:339–342
34. Takahashi K, Yamanaka S (2016) A decade of
transcription factor-mediated reprogramming
to pluripotency. Nat Rev Mol Cell Biol
17:183–193
35. Gierer A, Meinhardt H (1972) A theory of
biological pattern formation. Kybernetik
12:30–39
36.http://www.uoguelph.ca/~mgarvie/turing.
html
37. Chen TH, Guo C, Zhao X, Yao Y, Bostro ̈m KI,
Wong MN, Tintut Y, Demer LL, Ho CM,
Garfinkel A (2012) Patterns of periodic holes
created by increased cell motility. Interface
Focus 2:457–464
38. Pen ̃aB,Pe ́rez-Garcı ́a C (2001) Stability of
Turing patterns in the Brusselator model.
Phys Rev E Stat Nonlinear Soft Matter Phys
64:056213
39. Selvarajoo K (2012) Understanding multi-
modal biological decisions from single cell
and population dynamics. Wiley Interdiscip
Rev Syst Biol Med 4:385–399
40. Elowitz MB, Levine AJ, Siggia ED, Swain PS
(2002) Stochastic gene expression in a single
cell. Science 297:1183–1186
41. Swain PS, Elowitz MB, Siggia ED (2002)
Intrinsic and extrinsic contributions to stochas-
ticity in gene expression. Proc Natl Acad Sci U
S A 99:12795–12800
42. Kaern M, Elston TC, Blake WJ, Collins JJ
(2005) Stochasticity in gene expression: from
theories to phenotypes. Nat Rev Genet
6:451–464
43. Eldar A, Elowitz MB (2010) Functional roles
for noise in genetic circuits. Nature
467:167–173
44. Dunlop MJ, Cox RS III, Levine JH, Murray
RM, Elowitz MB (2008) Regulatory activity
revealed by dynamic correlations in gene
expression noise. Nat Genet 40:1493–1498
45. Blake WJ, KAErn M, Cantor CR, Collins JJ
(2003) Noise in eukaryotic gene expression.
Nature 422:633–637
46. Piras V, Tomita M, Selvarajoo K (2014)
Transcriptome-wide variability in single
embryonic development cells. Sci Rep 4:7137
47. Bizzarri M, Palombo A, Cucina A (2013) The-
oretical aspects of systems biology. Prog Bio-
phys Mol Biol 112:33–43
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