Systems Biology (Methods in Molecular Biology)

Table 2
Model result and experimental data at the molecular level

Model

results Experimental results

• HCC 1 HCC 2 HCC 3
  Molecular agents (Gene
  symbol)


• Agreement ratios
  24/37¼64.9%

Agreement ratios

29/37¼78.4%

Agreement ratios

25/37¼67.6%

Cyclin D-CDK4/6

(CCND1)

Up Up Up Up

Cyclin E-CDK2

(CCNE1)

Up Up Up Up

Rb (Rb1) Down Up Down Down

E2F (E2F4) Up Up Up Up

C/EBPα(CEBPA) Down Up Down Down

Foxa2 (FOXA2) Down Up Down Down

HNF4α(HNF4A) Down Down Down Down

Fas (Fas) Up Up Up Down

Bcl-2 (BCL2) Up Down Un-change Up

XIAP (XIAP) Up Up Up Up

Bax (BAX) Un-

change

Up Down Down

Bad (BAD) Up Up Down Down

Caspase 9 (CASP 9)/

Cytchrome c (CYCS)

Un-

change

Up Un-change Un-change

Caspase 8 (CASP8) Un-

change

Up Up Up

Caspase 3 (CASP3) Un-

change

Down Up Down

E-cadherin (CDH1) Down Down Down Down

Snail (SNAIL1) Up Up Up Up

Slug (SNAIL2) Up Up Up Up

Integrin (ITGB2) Up Up Up Up

Akt (AKT3) Up Up Up Up

PTEN (PTEN) Down Down Down Un-change

HIF (HIF1A) Up Up Up Un-change

TNFα(TNF) Up Up Down Up

NF-κB (RELA) Up Down Up Up

(continued)

226 Gaowei Wang et al.