Table 3
Prediction of top mutated genes in cancerous hepatocyte from model
Gene name Model result
Cyclin D-CDK4/6 Gain-of-function
Cyclin E-CDK2 Gain-of-function
Rb Loss-of-function
E2F Gain-of-function
C/EBPα Loss-of-function
Foxa2 Loss-of-function
HNF4α Loss-of-function
Fas Gain-of-function
Bcl-2/xL Gain-of-function
IAP Gain-of-function
Bax –
Bad –
Casp 9/Cytc –
Casp 8 –
Casp 3 –
E-cadherin Loss-of-function
Snail Gain-of-function
Slug Gain-of-function
Integrin Gain-of-function
Akt Gain-of-function
PTEN Loss-of-function
HIF Gain-of-function
TNFα Gain-of-function
IKK-NF-κB Gain-of-function
IKK-NF-κB (KC) Gain-of-function
IL-1 Gain-of-function
IL-6/stat Gain-of-function
EGF Gain-of-function
VEGF Gain-of-function
Ras Gain-of-function
ERK Gain-of-function
(continued)Endogenous Molecular-Cellular Network Cancer Theory 229