- Alberts B et al (2007) Molecular biology of
the cell. Garland Science, New York
- Smale S, Hirsch MW, Devaney RL (2003)
Differential equations, dynamical systems,
and an introduction to chaos. Elsevier Sci-
ence, Amsterdam
- Bar-Yam Y, Harmon D, de Bivort B (2009)
Attractors and democratic dynamics. Science
323(5917):1016–1017
- Ao P (2005) Laws in Darwinian evolutionary
theory. Phys Life Rev 2(2):117–156
- Matthias S, Sabine W (2008) Cancer as an
overhealing wound: an old hypothesis revis-
ited. Nat Rev Mol Cell Biol 9:628–638
- Williams CS, Mann M, DuBois RN (1999)
The role of cyclooxygenases in inflammation,
cancer, and development. Oncogene 18
(55):7908–7916
- El-Serag HB, Rudolph KL (2007) Hepatocel-
lular carcinoma: epidemiology and molecular
carcinogenesis. Gastroenterology 132
(7):2557–2576
- Hanahan D, Weinberg RA (2011) Hallmarks
of cancer: the next generation. Cell 144
(5):646–674
- Alberts B et al (2002) Molecular biology of
the cell. Garland Science Taylor & Francis
Group, New York
- Monga SPS (2010) Molecular pathology of
liver diseases. Springer, New York
- Tyson JJ, Chen KC, Novak B (2003) Sniffers,
buzzers, toggles and blinkers: dynamics of
regulatory and signaling pathways in the cell.
Curr Opin Cell Biol 15(2):221–231
- Ao P et al (2010) Towards predictive stochas-
tic dynamical modeling of cancer genesis and
progression. Interdiscip Sci Comput Life Sci 2
(2):140–144
- Shea MA, Ackers GK (1985) The OR control
system of bacteriophage lambda: a physical-
chemical model for gene regulation. J Mol
Biol 181(2):211–230
- Ao P et al (2007) Generic enzymatic rate
equation under living conditions. J Biol Syst
15(04):495–514
- Huang Y et al (2012) Identification of a
two-layer regulatory network of proliferation-
related microRNAs in hepatoma cells. Nucleic
Acids Res 40(20):10478–10493
- Holmes P (2005) Ninety plus thirty years of
nonlinear dynamics: less is more and more is
different. Int J Bifurcat Chaos 15
(09):2703–2716
- Zhu X-M et al (2004) Calculating biological
behaviors of epigenetic states in the phageλ
life cycle. Funct Integr Genomics 4
(3):188–195
- Lei X et al (2015) Biological sources of intrin-
sic and extrinsic noise in ci expression of lyso-
genic phage lambda. Sci Rep 5:13597
- Wang G et al (2016) Endogenous network
states predict gain or loss of functions for
genetic mutations in hepatocellular carci-
noma. J R Soc Interface 13(115):20151115
- Rosenberg SM (2001) Evolving responsively:
adaptive mutation. Nat Rev Genet 2
(7):504–515
- Cairns J, Overbaugh J, Miller S (1988) The
origin of mutants. Nature 335
(6186):142–145
- Cairns J (1998) Mutation and cancer: the
antecedents to our studies of adaptive muta-
tion. Genetics 148(4):1433–1440
- Bamford S et al (2004) The COSMIC (Cata-
logue of Somatic Mutations in Cancer) data-
base and website. Br J Cancer 91(2):355–358
- Forbes SA et al (2010) COSMIC (the Cata-
logue of Somatic Mutations in Cancer): a
resource to investigate acquired mutations in
human cancer. Nucleic Acids Res 38(Data-
base issue):D652–D657
- Nault J-C, Zucman-Rossi J (2014) Genetics
of hepatocellular carcinoma: the next genera-
tion. J Hepatol 60(1):224–226
- Rahman N (2014) Realizing the promise of
cancer predisposition genes. Nature 505
(7483):302–308
- Prives CL (2014) Abstract PL01-02: The two
faces of p53: tumor suppressor and oncogene.
Cancer Res 74(19 Supplement):PL01-
02–PL01-02
- Rubin H (2006) What keeps cells in tissues
behaving normally in the face of myriad muta-
tions? Bioessays 28(5):515–524
- Versteeg R (2014) Cancer: tumours outside
the mutation box. Nature 506
(7489):438–439
- Ingolia NT, Murray AW (2007) Positive-
feedback loops as a flexible biological Module.
Curr Biol 17(8):668–677
- Wang G et al (2014) Quantitative implemen-
tation of the endogenous molecular–cellular
network hypothesis in hepatocellular carci-
noma. Interface Focus 4(3):20130064
- Odom DT et al (2004) Control of pancreas
and liver gene expression by HNF transcrip-
tion factors. Science 303(5662):1378–1381
- Wang H et al (2001) C/EBPαarrests cell
proliferation through direct inhibition of
Cdk2 and Cdk4. Mol Cell 8(4):817–828
Endogenous Molecular-Cellular Network Cancer Theory 243
