366-C 22 APRIL 2022 • VOL 376 ISSUE 6591 science.org SCIENCE
variant and used functional and
structural studies to determine
how these antibodies recog-
nize the Omicron spike protein.
Their studies identify antibody
combinations with therapeutic
potential and could inform the
development of vaccines. —VV
Science, abm8897, this issue p. 369
CANCER THERAPY
Sensitizing AML
to kinase inhibitors
Although some acute myeloid
leukemia (AML) cells have
mutations that activate the MEK
kinase pathway, MEK inhibi-
tors are generally ineffective
in treating this cancer. Using
AML cells from patients and cell
lines, Pedicona et al. correlated
kinase network activity and
epigenetic markers (see the
Focus by Narayan and Huntly).
Inhibiting the epigenetic
modifying enzyme LSD1 rewired
kinase activity in AML cells and
sensitized them to subsequent
MEK inhibitor treatment. Thus,
activated MEK signaling might
be a source of resistance to
LSD1 inhibitors currently being
tested in AML patients. —LKF
Sci. Signal. 15 , eabl7989,
eabo0059 (2022).
FISHERIES
Pressure from both sides
It is now well established that
human activities impose selec-
tion that leads to evolutionary
change in wild species. Some
of the best examples of this
process are from harvested
species, especially fishes, and
we know that large-scale fishing
has led to effects such as early
maturation and changes in adult
size. Czorlich et al. looked at
native populations of Atlantic
salmon and found that even
indigenous fishing pressure
has led to evolutionary change
in these populations (see the
Perspective by Therkildsen and
Pinsky). They also identified
an additional indirect source
of selection: harvest of salmon
prey species at sea. —SNV
Science, abg5980, this issue p. 420;
see also abo6512, p. 344
SKIN INFLAMMATION
Gene interface tool
to identify your rash
Many chronic skin conditions
are caused by imbalances in the
immune milieu of the environ-
ment, yet many of these changes
remain undercharacterized. Liu
et al. used single-cell profiling of
immune cells from skin samples
of atopic dermatitis, psoriasis
vulgaris, and healthy controls to
profile the immune signatures
of the different diseases. They
found that atopic dermatitis
and psoriasis vulgaris samples
had distinct resident memory
T cell, innate lymphoid cell, and
CD8+ T cell gene signatures that
could be validated in an external
dataset. Using these signatures,
they created a tool that could
classify previously clinicopatho-
logically indeterminate rash
samples. This tool is now avail-
able as a web resource (RashX)
for anyone to use to help further
classify skin rashes. —DAE
Sci. Immunol. 7 , eabl9165 (2022).MICROBIOLOGY
Fungal pathogen
circumvents cellulose
Plant cell walls impede coloniza-
tion by fungal pathogens, and
crystalline cellulose has long been
regarded as the strongest compo-
nent of these walls. Studying the
plant pathogen Fusarium oxyspo-
rum, Gámez-Arjona et al. found
that deletion of an evolutionarily
conserved master regulator of
cellulose-degrading enzymes
does not result in compromised
virulence during early infection.
Instead, virulence is enhanced
by compensatory induction
of other virulence factors and
subversion of plant immune
responses. However, the patho-
gen is compromised during later
stages of growth and reproduc-
tion because of its inability
to metabolize cellulose as a
carbon source. These findings
prompt a different perspective
on the importance of cellulose-
degrading enzymes for fungal
colonization of plants. — JM
Sci. Adv. 10.1126/
sciadv.abl9734 (2022).SOLAR CELLS
Organometallics
stabilizing perovskites
Perovskite solar cells with
inverted (p-i-n) structure can
have greater stability and
lifetimes than conventional n-i-p
structures but usually have
somewhat lower power conver-
sion efficiencies (PCEs). Li et al.
report that an organometallic
compound, ferrocenyl-bis-thio-
phene-2-carboxylate, could
stabilize a multication perovskite
layer of an inverted perovskite
solar cell. After 1500 hours of
maximum power point opera-
tion, 98% of the 25.0% PCE was
maintained. The solar cell also
exhibited high stability in damp
heat tests. —PDS
Science, abm8566, this issue p. 416RESEARCH