sensing blocks abscess formation. Proc Natl
Acad Sci U S A 102:1691–1696
- McDowell P, Affas Z, Reynolds C, Holden
MT, Wood SJ, Saint S et al (2001) Structure,
activity and evolution of the group I thiolac-
tone peptide quorum-sensing system ofStaph-
ylococcusaureus. Mol Microbiol 41:503–512 - Tal-Gan Y, Stacy DM, Foegen MK, Koenig
DW, Blackwell HE (2013) Highly potent inhi-
bitors of quorum sensing in Staphylococcus
aureusrevealed through a systematic synthetic
study of the group-III autoinducing peptide. J
Am Chem Soc 135:7869–7882 - Gordon CP, Williams P, Chan WC (2013)
Attenuating Staphylococcusaureus virulence
gene regulation: a medicinal chemistry per-
spective. J Med Chem 56:1389–1404
- Todd DA, Zich DB, Ettefagh KA, Kavanaugh
JS, Horswill AR, Cech NB (2016) Hybrid
Quadrupole-Orbitrap mass spectrometry for
quantitative measurement of quorum
sensing inhibition. J Microbiol Methods
127:89–94 - Jensen RO, Winzer K, Clarke SR, Chan WC,
Williams P (2008) Differential recognition of
Staphylococcusaureusquorum-sensing signals
depends on both extracellular loops 1 and
2 of the transmembrane sensor AgrC. J Mol
Biol 381:300–309
96 Ewan J. Murray and Paul Williams