N
H 3 C
H
H
H 3 C
OH
CH 3
O
O
HO
CH 3
(23)
CHO
CHO
HO
COOH
(24)
n-C 7 H 15
O
HO OH
OEt
O
(25)
HO
O
O
OH
O
O
(26)
O
O
O
OH
O
O
(27)
Mangrove associates are species mainly distributed in terrestrial or aquatic
habitat but also occur in the mangrove ecosystem (Parani et al. 1998 ). According to
Tomlinson criteria, mangrove associates are also distinguished from true mangroves
by lacking aerial roots, vivipary, and no physiological mechanism for salt exclusion
(Wang et al. 2011 ). However, mangrove associates growing in the mangrove
habitat also have to face the same extreme ecological conditions as the true man-
groves. Therefore, these mangrove associates also have the potential of producing
bioactive natural products as the true mangroves. This is evident by the recent
report of Ratnaweera et al. ( 2016 ), who described the isolation of antimicrobial
gliotoxin(28)and Bisdethiobis (methylthio) gliotoxin(29)from an extract of the
endophytic fungusHypocrea virensfrom the plantPremna serratifoliafrom a
mangrove habitat.
Inland fresh water bodies also are productive ecosystems in the world which
house diverse microorganisms. Aquatic plants highly adapted to its environmental
and ecological conditions also harbor endophytic fungi having bioactive metabo-
lites. A recent investigation of endophytic fungi ofNymphaea nouchaliled to the
isolation of the known secondary metabolites chaetoglobosin A and C(30, 31)from
Chaetomium globosum, with chaetoglobisn A showing good antibacterial activities
(Dissanayaka et al. 2016 ).
202 P.B. Ratnaweera and E.D. de Silva