Natural Remedies in the Fight Against Parasites

[160] Guatam B, Lucia G, Suping J, Karl AW. Activity of Amidine‐containing Diphenylureas

Against P. falciparum. Letters in Drug Design & Discovery. 2005; 2 (2):162‐164.

doi:10.2174/1570180053175061

[161] Moura PA, Dame JB, Fidock DA. Role of Plasmodium falciparum digestive vacuole plas‐

mepsins in the specificity and antimalarial mode of action of cysteine and aspartic

protease inhibitors. Antimicrobial Agents and Chemotherapy. 2009; 53 (12):4968‐4978.

doi:10.1128/AAC.00882‐09

[162] Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, et al.

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export,

PfEMP1 display, and survival of malaria parasites. PLoS Biology. 2014; 12 (7):e1001897.

doi:10.1371/journal.pbio.1001897

[163] Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, et al. Transition

state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V

from P. falciparum and P. vivax. Journal of Medicinal Chemistry. 2014; 57 (18):7644‐7662.

doi:10.1021/jm500797g

[164] Gazdik M, Jarman KE, O'Neill MT, Hodder AN, Lowes KN, Jousset Sabroux H, et

al. Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibi‐

tor of the Plasmodium protease, plasmepsin V. Bioorganic & Medicinal Chemistry.

2016; 24 (9):1993‐2010. doi:10.1016/j.bmc.2016.03.027

[165] Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, et al. Structural

basis for plasmepsin V inhibition that blocks export of malaria proteins to human

erythrocytes. Nature Structural & Molecular Biology. 2015; 22 (8):590‐596. doi:10.1038/

nsmb.3061

218 Natural Remedies in the Fight Against Parasites