Stem Cell Microenvironments and Beyond

96

astrocyte

neural

stem cell

transit

amplifying

precursor

granule

neuron

blood

vessell

neuroblast

c

abSEZ SGZ

ependymal

cell

Fig. 6.2 Schematic illustrations of the cyto-architecture of the SEZ (in a) and of the SGZ (in b).
Note the NSCs of astroglial morphology (light blue cells) and the presence of blood vessels in
these neurovascular niches. (c) High magnification image of the human SEZ taken from a newborn
baby. The ependymal cell layer is at the right of the image (in white), Dcx + neuroblasts are at the
centre (in green) and an astrocyte-rich ribbon area at the left (GFAP+ cells in red); nuclei are coun-
terstained with Dapi (in blue). [Schemas in A, B reproduced from: The neural stem cell microen-
vironment (August 31, 2008), StemBook, ed. The Stem Cell Research Community, StemBook,
doi/https://doi.org/10.3824/stembook.1.15.1, http://www.stembook.org, under a Creative
Commons Attribution 3.0 Unported License]

E. Andreopoulou et al.